Technology Process of L-Proline,
1-[N-[1-(aminocarbonyl)-3-(benzoylamino)-4-phenylbutyl]-L-alanyl]-,
methyl ester
There total 14 articles about L-Proline,
1-[N-[1-(aminocarbonyl)-3-(benzoylamino)-4-phenylbutyl]-L-alanyl]-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
for 18h;
Ambient temperature;
DOI:10.1021/jm00382a008
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) triethylamine, ClCO2Et / 1.) ether, -15 deg C, 30 min, 2.) ether, 2 h
2: 76 percent / silver benzoate, triethylamine
3: 36 percent / Dibal-H / hexane; toluene / 1 h
4: TFA / 2 h
5: triethylamine / CH2Cl2 / 2 h
6: 39 percent / pyridinium chlorochromate / CH2Cl2 / 18 h
7: acetic acid / methanol / 72 h
8: 51 percent / HCl / 18 h / Ambient temperature
With
hydrogenchloride; silver benzoate; chloroformic acid ethyl ester; diisobutylaluminium hydride; acetic acid; triethylamine; pyridinium chlorochromate; trifluoroacetic acid;
In
methanol; hexane; dichloromethane; toluene;
DOI:10.1021/jm00382a008
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) triethylamine, ClCO2Et / 1.) ether, -15 deg C, 30 min, 2.) ether, 2 h
2: 76 percent / silver benzoate, triethylamine
3: 75 percent / diisobutylaluminum hydride / diethyl ether; hexane / 1 h / -78 °C
4: acetic acid / methanol / 48 h
5: 1.) HCl, 2.) di-tert-butyldicarbonate, triethylamine / 1.) RT, 72 h, 2.) CH2Cl2, 3 h
6: TFA / 18 h
7: 18 percent / triethylamine / CH2Cl2
With
hydrogenchloride; di-tert-butyl dicarbonate; silver benzoate; chloroformic acid ethyl ester; diisobutylaluminium hydride; acetic acid; triethylamine; trifluoroacetic acid;
In
methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm00382a008
