Technology Process of Carbamic acid, (4,4-diethyltetrahydro-5-oxo-3-furanyl)-, phenylmethyl
ester, (S)-
There total 3 articles about Carbamic acid, (4,4-diethyltetrahydro-5-oxo-3-furanyl)-, phenylmethyl
ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / thionyl chloride / ethyl acetate / 1 h / Ambient temperature
2: 1.) sodium borohydride; 2.) HCl / 1.) THF, 0 deg C, 15 min, r.t. 1 h; 2.) EtOH, reflux 1,5 h
3: 1.) LDA; 2.) HMPT / 1.) THF, -78 deg C; 2.) -78 - 0 deg C, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; lithium diisopropyl amide;
In
ethyl acetate;
DOI:10.1248/cpb.34.3020
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) sodium borohydride; 2.) HCl / 1.) THF, 0 deg C, 15 min, r.t. 1 h; 2.) EtOH, reflux 1,5 h
2: 1.) LDA; 2.) HMPT / 1.) THF, -78 deg C; 2.) -78 - 0 deg C, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium diisopropyl amide;
DOI:10.1248/cpb.34.3020
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
Yield given. Multistep reaction. Yields of byproduct given;
1.) THF, -78 deg C; 2.) -78 - 0 deg C, 1 h;
DOI:10.1248/cpb.34.3020
