2-Furanamine

Base Information

• Chemical Name: 2-Furanamine
• CAS No.: 29212-67-7
• Molecular Formula: C4H5 N O
• Molecular Weight: 83.0898
• Mol file: 29212-67-7.mol

Synonyms:2-Aminofuran

Chemical Property of 2-Furanamine

Chemical Property:

• Boiling Point: 147.5°Cat760mmHg
• PKA: 1.46±0.10(Predicted)
• Flash Point: 43°C
• PSA: 39.16000
• Density: 1.115g/cm³
• LogP: 1.44300

Purity/Quality:

NLT 98% ^*data from raw suppliers

FURAN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Furanamine

There total 1 articles about 2-Furanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-furyl)-2,3,4,5-tetraphenylcyclopentadienimine (91550-23-1) → 2-aminofuran (29212-67-7) + 2,3,4,5-tetraphenylcyclopenta-2,4-dien-1-one oxime (91550-26-4)

Guidance literature:

With hydroxylamine; In pyridine; water;

DOI:10.1021/ja00331a069

Reference yield: 89.4%

4-(pyrrolidin-1-yl)benzaldehyde (51980-54-2) + 2-aminofuran (29212-67-7) + Dimethyl phosphite (868-85-9) → C17H23N2O4P

Guidance literature:

With zinc tetrafluoroborate; In water; at 20 ℃; for 0.666667h;

DOI:10.2174/1570180813666160722123045

Reference yield: 88.0%

1,3-bis-(4-chloro-phenyl)-5-(2-oxo-2-phenyl-ethyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (917508-99-7) + 2-aminofuran (29212-67-7) → 1,3-bis(4-chlorophenyl)-7-(furan-2-yl)-6-phenyl-2-thioxo-1,2,3,7-tetrahydropyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:

With Montmorillonite K-10 clay; at 130 - 140 ℃; for 0.0583333h; microwave irradiation;

DOI:10.1002/jhet.5570430514

upstream raw materials:

N-(2-furyl)-2,3,4,5-tetraphenylcyclopentadienimine

Downstream raw materials:

2-Amino-N-furan-2-yl-benzamide

(2,6-dichlorobenzylidene)furan-2-ylamine

furan-2-yl(3-nitrobenzylidene)amine

(2,4-dichlorobenzylidene)furan-2-ylamine

Refernces

Acid-induced and reductive transformations of enantiopure 3,6-dihydro-2H-1,2-oxazines - Synthesis of dideoxyamino carbohydrate derivatives

10.1002/ejoc.200700792

The study investigates the acid-induced and reductive transformations of enantiopure 3,6-dihydro-2H-1,2-oxazines, which are carbohydrate-derived heterocycles. These oxazines, synthesized from lithiated alkoxyallenes and chiral carbohydrate-derived nitrones via a [3+3] cyclization, serve as versatile intermediates for creating various target compounds. Acid-catalyzed transformations of these oxazines yield enantiopure furano-1,2-oxazines or pyrano-1,2-oxazines, with reaction conditions dictating the degree of solvolysis. The N–O bond of these oxazines can be reductively cleaved using hydrogen/palladium or samarium diiodide, resulting in enantiopure aminofuran and aminopyran derivatives. These derivatives are essentially protected 4-amino-1,4-dideoxyhex-3-ulose or 4-amino-1,4-dideoxyoct-3-ulose derivatives, representing a short and stereocontrolled route to amino carbohydrate derivatives. The study also includes X-ray analysis of certain products to confirm their structures and investigate hydrogen bonding networks.