Ethyl quinoline-2-carboxylate

Base Information

• Chemical Name: Ethyl quinoline-2-carboxylate
• CAS No.: 4491-33-2
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Hs Code.: 2933499090
• Mol file: 4491-33-2.mol

Synonyms:Ethyl 2-quinolinecarboxylate

Chemical Property of Ethyl quinoline-2-carboxylate

Chemical Property:

• Vapor Pressure: 1.95E-05mmHg at 25°C
• Melting Point: 30-33 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.643
• Boiling Point: 333.9 °C at 760 mmHg
• PKA: 2.07±0.40(Predicted)
• Flash Point: 155.8 °C
• PSA: 39.19000
• Density: 1.175 g/cm³
• LogP: 2.41150
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethylquinoline-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl quinoline-2-carboxylate

There total 5 articles about Ethyl quinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-Chloroquinoline (612-62-4) + chloroethane (75-00-3) + carbon dioxide (124-38-9,18923-20-1) → quinoline (91-22-5) + ethyl quinoline-2-carboxylate (4491-33-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; electrolysis, -2.0 V;

Reference yield: 22.0%

quinoline (91-22-5) + chloroethane (75-00-3) + carbon dioxide (124-38-9,18923-20-1) → ethyl quinoline-2-carboxylate (4491-33-2) + 2,2'-biquinoline (119-91-5)

Guidance literature:

With tetraethylammonium iodide; In N,N-dimethyl-formamide; electrochemically;

Reference yield: 20.0%

2-Chloroquinoline (612-62-4) → quinoline (91-22-5) + ethyl quinoline-2-carboxylate (4491-33-2)

Guidance literature:

With chloroethane; carbon dioxide; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; electrolysis, -2.0 V;

upstream raw materials:

2-oxo-propionic acid ethyl ester

quinoline

chloroethane

carbon dioxide

Downstream raw materials:

1-(2-chinolinyl)-3-phenyl-propane-1,3-dione

5-(2-quinolyl)-3-phenylpyrazole

Refernces

• 1、 Heinisch, Gottfried,Loetsch, Gerhard. "HOMOLYTIC ALKOXYCARBONYLATION REACTIONS IN TWO-PHASE SYSTEMS, PART II. STUDIES ON THE ETHOXYCARBONYLATION OF SOME SELECTED ?-DEFICIENT N-HETEROAROMATIC SYSTEMS". . p. 5973 - 5977. Retrieved 2007/10/02.