1-Cyclohexylbiguanide monohydrochloride

Base Information

• Chemical Name: 1-Cyclohexylbiguanide monohydrochloride
• CAS No.: 4762-22-5
• Molecular Formula: C8H18ClN5
• Molecular Weight: 219.717
• European Community (EC) Number: 225-300-0
• NSC Number: 20215
• Mol file: 4762-22-5.mol

Synonyms:4762-22-5;1-Cyclohexylbiguanide monohydrochloride;N-cyclohexyl-N'-(diaminomethylene)guanidine hydrochloride;15233-32-6;1-carbamimidamido-N-cyclohexylmethanimidamide hydrochloride;2-cyclohexyl-1-(diaminomethylidene)guanidine;hydrochloride;N-cyclohexylbiguanide hydrochloride;C8H18ClN5;SCHEMBL11818439;NSC20215;MFCD08582827;NSC-20215;AKOS024332832;N-Cyclohexyl-N'-(diaminomethylene)guanidine HCl;A921116;N-cyclohexylimidodicarbonimidic diamide hydrochloride;N-cyclohexyl-N'-(diaminomethylene)guanidinehydrochloride

Chemical Property of 1-Cyclohexylbiguanide monohydrochloride

Chemical Property:

• Vapor Pressure: 8.49E-06mmHg at 25°C
• Melting Point: 225-227 °C(Solv: water (7732-18-5))
• Boiling Point: 374.2°Cat760mmHg
• Flash Point: 180.1°C
• PSA: 97.78000
• Density: 1.38g/cm³
• LogP: 2.81010
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 219.1250733
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

N-cyclohexylbiguanideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N=C(N)N=C(N)N.Cl

Technology Process of 1-Cyclohexylbiguanide monohydrochloride

There total 1 articles about 1-Cyclohexylbiguanide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylamine hydrochloride (4998-76-9) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → 1-cyclohexyl-biguanide; hydrochloride (4762-22-5)

Guidance literature:

at 130 - 150 ℃;

DOI:10.1016/0223-5234(93)90007-2

Reference yield: 75.0%

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane (423-39-2) + 1-cyclohexyl-biguanide; hydrochloride (4762-22-5) → N2-cyclohexyl-6-(perfluoropropyl)-1,3,5-triazine-2,4-diamine (1492-85-9)

Guidance literature:

1-cyclohexyl-biguanide; hydrochloride; With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane; In N,N-dimethyl-formamide; at 20 ℃; Irradiation;

DOI:10.1021/acs.orglett.9b00655

Reference yield: 74.0%

1-cyclohexyl-biguanide; hydrochloride (4762-22-5) + methyl (1,3-benzothiazol-2-ylsulfanyl)acetate (24044-87-9) → 2-amino-6-(benzothiazolyl-2-thiomethyl)-4-cyclohexylamino-sym-triazine

Guidance literature:

1-cyclohexyl-biguanide; hydrochloride; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

methyl (1,3-benzothiazol-2-ylsulfanyl)acetate; In methanol; for 10h; Heating;

DOI:10.1023/A:1025102300933

upstream raw materials:

cyclohexylamine hydrochloride

N-Cyanoguanidine

Downstream raw materials:

N²-cyclohexyl-6-(perfluoropropyl)-1,3,5-triazine-2,4-diamine