2-PYRIDIN-3-YL-1H-INDOLE

Base Information

• Chemical Name: 2-PYRIDIN-3-YL-1H-INDOLE
• CAS No.: 15432-24-3
• Molecular Formula: C13H10 N2
• Molecular Weight: 194.23
• Hs Code.: 2933990090
• Mol file: 15432-24-3.mol

Synonyms:Indole,2-(3-pyridyl)- (6CI,7CI,8CI); 2-(3-Pyridyl)indole

Chemical Property of 2-PYRIDIN-3-YL-1H-INDOLE

Chemical Property:

• Vapor Pressure: 7.07E-07mmHg at 25°C
• Melting Point: 178-179 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 420.1°Cat760mmHg
• PKA: 15.78±0.30(Predicted)
• Flash Point: 192.9°C
• PSA: 28.68000
• Density: 1.211g/cm³
• LogP: 3.22990
• Sensitive.: Light Sensitive

Purity/Quality:

97% ^*data from raw suppliers

2-(pyridin-3-yl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDIN-3-YL-1H-INDOLE

There total 20 articles about 2-PYRIDIN-3-YL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 2-(3-pyridinyl)-1H-indole-1-carboxylate (157427-58-2) → 2-(pyridin-3-yl)-indole (15432-24-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo00094a042

Reference yield: 86.0%

N-phenyl-N'-(1-pyridin-3-yl-ethylidene)-hydrazine (5973-84-2) → 2-(pyridin-3-yl)-indole (15432-24-3)

Guidance literature:

With PPA; at 180 ℃;

DOI:10.1016/j.bmc.2004.07.031

Reference yield: 85.0%

3-pyridinecarboxaldehyde (500-22-1) + (2-aminobenzyl)triphenylphosphonium bromide (78133-84-3) → 2-(pyridin-3-yl)-indole (15432-24-3)

Guidance literature:

3-pyridinecarboxaldehyde; (2-aminobenzyl)triphenylphosphonium bromide; With acetic acid; In methanol; at 80 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

With potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801034x

upstream raw materials:

3-acetyl pyridine-phenyl hydrazone

o-[2-(pyridin-3-yl)ethynyl]aniline

tert-butyl 2-(3-pyridinyl)-1H-indole-1-carboxylate

C₂₆H₁₈N₄S₂

Downstream raw materials:

1-[(4,5-Dihydro-1H-imidazol-2-yl)-(2-pyridin-3-yl-1H-indol-3-ylmethyl)-amino]-butan-1-ol; hydriodide

3-(benzo[b]thiophen-2-yl)piperidine