Ethyl 2-hydroxy-4,6-diMethylnicotinate

Base Information

• Chemical Name: Ethyl 2-hydroxy-4,6-diMethylnicotinate
• CAS No.: 16108-48-8
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Hs Code.: 2933399090
• Mol file: 16108-48-8.mol

Synonyms:Nicotinicacid, 1,2-dihydro-4,6-dimethyl-2-oxo-, ethyl ester (8CI); Nicotinic acid, 2-hydroxy-4,6-dimethyl-,ethyl ester (7CI); NSC 61971

Chemical Property of Ethyl 2-hydroxy-4,6-diMethylnicotinate

Chemical Property:

• Vapor Pressure: 1.07E-05mmHg at 25°C
• Melting Point: 136 °C
• Boiling Point: 371°Cat760mmHg
• PKA: 10.30±0.10(Predicted)
• Flash Point: 178.2°C
• PSA: 59.16000
• Density: 1.124g/cm³
• LogP: 1.16840

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-hydroxy-4,6-diMethylnicotinate

There total 26 articles about Ethyl 2-hydroxy-4,6-diMethylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-amino-3-penten-2-one (1118-66-7) + ethyl 2-cyanoacetate (105-56-6) → ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate (16108-48-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 65 ℃; for 36h;

Reference yield: 76.0%

4-(phenylamino)pent-3-en-2-one (7294-89-5,26567-78-2,147054-81-7) + ethyl 2-cyanoacetate (105-56-6) → 3-ethoxycarbonyl-4,6-dimethyl-1-phenyl-2(1H)-pyridone (113123-58-3) + ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate (16108-48-8)

Guidance literature:

With triethylamine;

Reference yield: 61.0%

2-ethoxycarbonylmethyl-2-hydroxy-1,4,6-trimethyl-1,2-dihydropyrimidine (622849-35-8) → ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate (16108-48-8) + 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester (22114-32-5)

Guidance literature:

In ethanol; for 10h; Heating;

DOI:10.1007/s10593-006-0161-8

upstream raw materials:

ethyl 2-cyanoacetate

acetylacetone

2,4-dioxo-valeric acid amide

diethyl malonate

Downstream raw materials:

2-hydroxy-4,6-dimethylnicotinic acid

6-Hydroxy-2,4-lutidin

Ethyl 1-(4-fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate

3-ethoxycarbonyl-4,6-dimethyl-1-phenyl-2(1H)-pyridone

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