Methyl 2-chloro-4,6-diMethylnicotinate

Base Information

• Chemical Name: Methyl 2-chloro-4,6-diMethylnicotinate
• CAS No.: 339151-88-1
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.6342
• Hs Code.: 2933399090
• Mol file: 339151-88-1.mol

Synonyms:Methyl 2-chloro-4,6-diMethylnicotinate;2-Chloro-4,6-diMethyl-nicotinic acid Methyl ester;2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid methyl ester

Chemical Property of Methyl 2-chloro-4,6-diMethylnicotinate

Chemical Property:

• Boiling Point: 271.7±35.0 °C(Predicted)
• PKA: 0.37±0.10(Predicted)
• PSA: 39.19000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 2.13840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-chloro-4,6-dimethylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloro-4,6-diMethylnicotinate

There total 2 articles about Methyl 2-chloro-4,6-diMethylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methanol (67-56-1) + ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate (16108-48-8) → methyl 2-chloro-4,6-dimethylnicotinate (339151-88-1)

Guidance literature:

ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate; With phosphorus pentachloride; at 120 ℃; for 0.5h;

methanol; Further stages.;

DOI:10.1021/ja0035699

Reference yield:

methanol (67-56-1) + 2-chloro-4,6-dimethylnicotinic acid (66662-48-4) → methyl 2-chloro-4,6-dimethylnicotinate (339151-88-1)

Guidance literature:

2-chloro-4,6-dimethylnicotinic acid; With thionyl chloride; at 80 ℃; for 2h;

methanol; at 0 - 20 ℃; for 16h;

upstream raw materials:

methanol

ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate

2-chloro-4,6-dimethylnicotinic acid

Refernces

• 1、 Kita,Higuchi,Yoshida,Iio,Kitagaki,Ueda,Akai,Fujioka. "Enantioselective total synthesis of a potent antitumor antibiotic, fredericamycin A". . p. 3214 - 3222. Retrieved 2007/10/03.