Progesterone EP Impurity C

Base Information

• Chemical Name: Progesterone EP Impurity C
• CAS No.: 145-15-3
• Molecular Formula: C21H32O2
• Molecular Weight: 316.484
• European Community (EC) Number: 205-650-0
• Wikipedia: 20%CE%B2-Dihydroprogesterone
• Mol file: 145-15-3.mol

Synonyms:145-15-3;(8S,9R,10S,13S,14S,17S)-17-[(1R)-1-Hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;Progesterone EP Impurity C;Progesterone BP Impurity C;(20R)-Dihydro Progesterone;(20R)-20-Hydroxypregn-4-en-3-one

Chemical Property of Progesterone EP Impurity C

Chemical Property:

• Melting Point: 158-160 °C
• Boiling Point: 451.7 °C at 760 mmHg
• PKA: 15.05±0.20(Predicted)
• Flash Point: 192.4 °C
• PSA: 37.30000
• Density: 1.09 g/cm³
• LogP: 4.51530
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), Dichloromethane (Slightly), Meth
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 316.240230259
• Heavy Atom Count: 23
• Complexity: 550

Purity/Quality:

97% ^*data from raw suppliers

20β-Dihydroprogesterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O
• Isomeric SMILES: C[C@H]([C@H]1CC[C@@H]2[C@@]1(CC[C@@H]3[C@H]2CCC4=CC(=O)CC[C@@]34C)C)O
• Uses: 20β-Dihydroprogesterone is an impurity of Progesterone (P755900), a steroid hormone secreted by the corpus luteum. Progesterone have various significant physiological roles, such as inducing the matur ation and secretory activities of the uterine endothelium and the suppression of ovulation. Progesterone is also implicated in the etiology of breast cancer. 20β-Dihydroprogesterone (Progesterone EP Impurity C) is an impurity of Progesterone (P755900), a steroid hormone secreted by the corpus luteum. Progesterone have various significant physiological roles, such as inducing the maturation and secretory activities of the uterine endothelium and the suppression of ovulation. Progesterone is also implicated in the etiology of breast cancer.

Technology Process of Progesterone EP Impurity C

There total 30 articles about Progesterone EP Impurity C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,3-ethylenedioxy-20(R)-hydroxy-4-pregnene → 20α-hydroxyprogesterone (145-15-3)

Guidance literature:

With toluene-4-sulfonic acid; In acetone;

DOI:10.1016/j.tet.2007.12.006

Reference yield:

Pregnenolone (145-13-1) → Progesterone (57-83-0) + 20α-hydroxyprogesterone (145-15-3) + (20R)-20-Hydroxy-5-pregnen-3-on (566-64-3) + 11β-hydroxy-20α-dihydroprogesterone (2640-53-1)

Guidance literature:

With calf serum horse serum; Ham's F-10 medium; MEN medium; mouse adrenal Y-1 cells transformed by simian adenovirus SA-7; at 37 ℃; for 60h; Product distribution;

DOI:10.1016/S0039-128X(81)90294-4

Reference yield:

Pregnenolone (145-13-1) → Progesterone (57-83-0) + 20α-hydroxyprogesterone (145-15-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Product distribution; Heating; effect of the presence of AlCl₃;

upstream raw materials:

progesterone

3-pyrrolidino-pregna-3,5-dien-20-one

Progesterone

Pregnenolone

Downstream raw materials:

7α-methyl-4-pregnene-3,20-dione

20β_F-acetoxy-pregn-4-en-3-one

20β_F-hydroxy-A-nor-pregn-3-en-2-one

Progesteron-3-(O-carboxymethyl)-oxim