Refernces
10.1021/ic990773s
The research focuses on the synthesis, spectroscopic characterization, crystal structure, and theoretical calculations of the dinuclear nickel(0) complex [Ni2(μ-CO)(CO)2(μ-dppa)2] (where dppa is bis(diphenylphosphino)amine). The complex was synthesized via two methods, yielding a stable microcrystalline yellow solid. The first method involved the reaction of Ni(CO)4 with the dppa ligand in benzene, while the second method used NiCl2·6H2O with dppa in methanol and sodium tetrahydroborate as a reducing agent with carbon monoxide. The synthesized complex was characterized using elemental analysis, infrared (IR) spectroscopy, proton and phosphorus-31 nuclear magnetic resonance (1H and 31P NMR), and cyclic voltammetry. The crystal structure was determined through X-ray diffraction, revealing a triclinic crystal system with a P1 space group and specific unit cell dimensions. Theoretical calculations using a semiempirical PM3 Hamiltonian were also conducted to predict bond orders and reactivity, supported by the Fukui function analysis. The complex was found to absorb carbon monoxide, leading to the formation of a mixture of nickel carbonyl compounds, and showed electrochemical behavior indicative of successive oxidation of the metal centers.
10.1002/asia.201700538
The research focuses on the development of an efficient peptide synthesis approach through a one-pot aziridine-mediated ligation-desulfurization strategy, specifically targeting the incorporation of phenylalanine and tryptophan residues into α-peptides. The methodology involves the regioselective ring-opening of aziridine-3-aryl-2-carboxylates with peptide thioacids, followed by desulfurization to yield the desired peptides. Key reactants include 3-phenyl- and 3-indolyl-substituted aziridin-2-carboxylates derivatives, synthesized from (2S,3R) β-hydroxy–α-azidophenylalanine and N-protected (2S,3R) β-hydroxy–α-azidotryptophan, and various peptide thioacids such as Boc-L-Val-SH. The experiments utilized solvents like DMF, DCM, THF, and ethanol, with reagents such as NaBH4/NiCl2.6H2O for the desulfurization step. The optimization of reaction conditions was conducted to maximize yields, and the scope of the method was explored with different peptide thioacids. Analyses included TLC monitoring, 1H NMR, and LC-HRMS to characterize intermediates and final products, confirming the regioselective formation of α-peptides with phenylalanine and tryptophan.
10.1016/j.tetlet.2012.02.081
The study presents a method for the N-arylation of amines and NH-heterocycles using NiCl2·6H2O as a recyclable heterogeneous catalyst under microwave exposure. The primary chemicals used include aryl halides, various amines, and NH-heterocycles as substrates for the coupling reaction, NiCl2·6H2O as the catalyst, and triethylamine (Et3N) as the base. These chemicals serve the purpose of forming carbon-nitrogen bonds in the synthesis of aryl amines, which are important in the production of drugs, materials, natural products, agrochemicals, and optical devices. The study highlights the advantages of using microwave energy for heating chemical reactions, which include reduced reaction times, increased product yields, and enhanced product purities. The process is solvent-free, does not require ligands, and the catalyst can be easily recovered and reused, making the protocol convenient, rapid, economical, and environmentally friendly.
10.1016/j.molliq.2014.07.039
This research aimed to develop an efficient, green, and one-pot synthesis method for 1,3-thiazolidin-4-one using a magnetically recyclable ionic liquid (ILs) supported on FeNi3 nanocatalyst. The purpose was to create a highly active and stable catalyst with high densities of functional groups under solvent-free conditions, utilizing rapid and easy immobilization techniques and low-cost precursors. The study successfully synthesized FeNi3-ILs nanoparticles, characterized them, and demonstrated their catalytic activity, achieving high to excellent yields of 1,3-thiazolidin-4-ones. The catalyst was found to be easily recoverable and reusable without significant loss of activity. Key chemicals used in the process included FeCl2·4H2O, NiCl2·6H2O, ammonium hydroxide, hydrazine hydrate, tetraethyl orthosilicate (TEOS), chlorosulfonic acid, and ethanolamine. The research concluded that FeNi3-ILs MNPs are a promising catalyst for the efficient one-pot synthesis of 1,3-thiazolidin-4-one and contribute to the development of new catalytic systems for organic synthesis.
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T:Toxic;
