Benzenemethanamine, a-[[3-(4-chlorophenyl)-5-isothiazolyl]methylene]-4-methyl-, (Z)-

Base Information

Chemical Name:Benzenemethanamine, a-[[3-(4-chlorophenyl)-5-isothiazolyl]methylene]-4-methyl-, (Z)-
CAS No.:95514-28-6
Molecular Formula:C18H15ClN2S
Molecular Weight:326.849
Hs Code.:

Synonyms:

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Chemical Property of Benzenemethanamine, a-[[3-(4-chlorophenyl)-5-isothiazolyl]methylene]-4-methyl-, (Z)-

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Technology Process of Benzenemethanamine, a-[[3-(4-chlorophenyl)-5-isothiazolyl]methylene]-4-methyl-, (Z)-

There total 10 articles about Benzenemethanamine, a-[[3-(4-chlorophenyl)-5-isothiazolyl]methylene]-4-methyl-, (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 95514-42-4
3-(p-chlorophenyl)-5-<2-<(tert-butyldimethylsilyl)amino>-2-p-tolylvinyl>isothiazole

: 95514-28-6
3-(p-chlorophenyl)-5-(2-amino-2-p-tolylvinyl)isothiazole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/ja00295a026

Reference yield:

: 91182-87-5
3-(p-chlorophenyl)-5-methylisoxazole-4-carboxylic acid

: 95514-28-6
3-(p-chlorophenyl)-5-(2-amino-2-p-tolylvinyl)isothiazole

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / sodium hydroxide, hydrogen / Raney nickel (W₂) / H₂O / Ambient temperature

2: 1.) sodium hydrogen carbonate, phosphorus pentasulfide; 2.) chloranil / 1.) THF, room t.

3: 98 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

4: 45 percent / n-butyllithium / tetrahydrofuran; hexane

5: 57 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / -78 °C

With diphosphorus pentasulfide; sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; chloranil; sodium hydrogencarbonate; lithium diisopropyl amide; Raney Nickel (W₂); In tetrahydrofuran; hexane; water;
DOI:10.1021/ja00295a026

Reference yield:

: 68870-58-6
methyl 3-(p-chlorophenyl)-5-methylisoxazole-4-carboxylate

: 95514-28-6
3-(p-chlorophenyl)-5-(2-amino-2-p-tolylvinyl)isothiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / potassium hydroxide / ethanol; H₂O / 10 h / Heating

2: 51 percent / sodium hydroxide, hydrogen / Raney nickel (W₂) / H₂O / Ambient temperature

3: 1.) sodium hydrogen carbonate, phosphorus pentasulfide; 2.) chloranil / 1.) THF, room t.

4: 98 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

5: 45 percent / n-butyllithium / tetrahydrofuran; hexane

6: 57 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / -78 °C

With diphosphorus pentasulfide; potassium hydroxide; sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; chloranil; sodium hydrogencarbonate; lithium diisopropyl amide; Raney Nickel (W₂); In tetrahydrofuran; ethanol; hexane; water;
DOI:10.1021/ja00295a026