91182-87-5

Usage

Uses

Used in Organic Synthesis:
3-(4-CHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-(4-CHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID is used as a starting material or intermediate in the development of new drugs. Its potential biological activity and structural features make it a promising candidate for the discovery of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug design.

Upstream product

• 97026-71-6 (3-(4-chlorophenyl)-5-methyl)isoxazole-4-carboxylic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 68870-58-6 methyl 3-(p-chlorophenyl)-5-methylisoxazole-4-carboxylate 

Downstream Products

• 95514-23-1 1-amino-1-(p-chlorophenyl)-1-buten-3-one 
• 95514-22-0 1-amino-1-(p-chlorophenyl)-3-oxo-1-buten-2-carboxylic acid 
• 127426-59-9 3-(4-chlorophenyl)-5-methylisoxazole-4-carboxaldehyde 
• 91063-34-2 3-(4-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid amide 
• 21106-64-9 6β-[3-(4-chloro-phenyl)-5-methyl-isoxazole-4-carbonylamino]-penicillanic acid 
• 95514-45-7 (E)-3-(p-chlorophenyl)-5-<2-(p-chlorophenyl)vinyl>isothiazole 
• 95514-46-8 (Z)-3-(p-chlorophenyl)-5-<2-(p-chlorophenyl)vinyl>isothiazole 
• 95514-34-4 (Z)-2-[3-(4-Chloro-phenyl)-isothiazol-5-yl]-1-(2,6-dichloro-phenyl)-vinylamine 
• 95514-35-5 (Z)-1-(4-Chloro-phenyl)-2-[3-(2,6-dichloro-phenyl)-isothiazol-5-yl]-vinylamine 
• 95514-37-7 3-(p-chlorophenyl)-5-(p-chlorophenacyl)isothiazole 
• 95514-30-0 (Z)-2-[3-(4-Chloro-phenyl)-isothiazol-5-yl]-1-(4-fluoro-phenyl)-vinylamine 
• 95514-31-1 (Z)-1-(4-Chloro-phenyl)-2-[3-(4-fluoro-phenyl)-isothiazol-5-yl]-vinylamine 
• 95514-39-9 3-(p-chlorophenyl)-5-<(trimethylsilyl)methyl>isothiazole 
• 95514-43-5 3-(p-chlorophenyl)-5-<2-<(tert-butyldimethylsilyl)amino>-2-(3,5-dichlorophenyl)vinyl>isothiazole 

Relevant academic research and scientific papers

Synthesis and biological activity of ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylate

A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates I-1-6 were synthesized. The structures of all target compounds were characterized by 1H NMR, 13C NMR, IR,MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds I-4 possess 20-50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds I-1-5 possess 32-58% inhibition against FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers and Fusarium oxysporum in vitro at the concentration of 100 mg/L.

Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists

A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described.

Ring Transformation Equilibrium (Bond Switch) in the 5-(2-Aminovinyl)isothiazole System via Hypervalent Sulfurane. Synthesis, Structure Determination, and Kinetic Study

Reaction of 3-aryl-5-methylisothiazoles (4) with aromatic nitriles afforded the adducts 3, 5-(2-amino-2-arylvinyl)-3-arylisothiazole derivatives, in the presence of LDA.By employing p-chlorobenzonitrile-15N, the presence of ring transformation from one is