6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine

Base Information

Chemical Name:6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine
CAS No.:95601-81-3
Molecular Formula:C24H18Br2N2
Molecular Weight:494.228
Hs Code.:
DSSTox Substance ID:DTXSID30537894
Wikidata:Q82413040

Synonyms:95601-81-3;6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine;DTXSID30537894

Suppliers and Price of 6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine

Chemical Property:

XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:493.98162
Heavy Atom Count:28
Complexity:416

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC(=C1)C2=CC=CC(=N2)C3=CC=C(C=C3)CBr)C4=CC=C(C=C4)CBr

Technology Process of 6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine

There total 4 articles about 6,6'-Bis[4-(bromomethyl)phenyl]-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 95601-80-2
6,6'-bis(4-(methoxymethyl)phenyl)-2,2'-bipyridine

: 95601-81-3
6,6'-bis(4-(bromomethyl)phenyl)-2,2'-bipyridine

Guidance literature:: With hydrogen bromide; In acetic acid; at 25 ℃; for 48h;
DOI:10.1016/S0040-4039(01)91255-9

Reference yield:

: 49669-22-9
6,6'-Dibromo-2,2'-bipyridine

: 95601-81-3
6,6'-bis(4-(bromomethyl)phenyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (PPh₃)2NiCl₂ / 1.) Et₂O, reflux, 15 min; 2.) THF, 75 min.

2: 66 percent / HBr / acetic acid / 48 h / Ambient temperature

With bis(triphenylphosphine)nickel(II) chloride; hydrogen bromide; In acetic acid;
DOI:10.1021/jo00212a016

Reference yield:

: 1515-88-4
1-bromo-4-methoxymethylbenzene

: 95601-81-3
6,6'-bis(4-(bromomethyl)phenyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) (PPh₃)2NiCl₂ / 1.) preparation of Grignard reagent 2.) Et₂O, reflux

2: 66 percent / HBr / acetic acid / 48 h / 25 °C

With hydrogen bromide; bis(triphenylphosphine)nickel(II) chloride; In acetic acid;
DOI:10.1016/S0040-4039(01)91255-9