1-Bromo-4-(methoxymethyl)benzene

Base Information

• Chemical Name: 1-Bromo-4-(methoxymethyl)benzene
• CAS No.: 1515-88-4
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 29093090
• European Community (EC) Number: 625-449-5
• DSSTox Substance ID: DTXSID20506059
• Nikkaji Number: J265.457A
• Wikidata: Q82361622
• Mol file: 1515-88-4.mol

Synonyms:1-Bromo-4-(methoxymethyl)benzene;1515-88-4;4-Bromobenzyl methyl ether;Benzene, 1-bromo-4-(methoxymethyl)-;MFCD09265134;p-methoxymethyl-bromobenzene;4-(methoxymethyl)bromobenzene;SCHEMBL1995347;SCHEMBL6245694;DTXSID20506059;4-Bromobenzyl methyl ether, 97%;(4-Bromophenyl)methyl methyl ether;4-Bromobenzyl alcohol, methyl ether;AKOS010793496;AM90057;BS-21538;SY068769;CS-0149213;FT-0742612;EN300-122775;N10190;J-008821

Chemical Property of 1-Bromo-4-(methoxymethyl)benzene

Chemical Property:

• Vapor Pressure: 0.193mmHg at 25°C
• Melting Point: -15 °C (lit.)
• Refractive Index: n20/D 1.5470(lit.)
• Boiling Point: 217.635 °C at 760 mmHg
• Flash Point: 85.885 °C
• PSA: 9.23000
• Density: 1.389 g/cm³
• LogP: 2.59550
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 199.98368
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%Min ^*data from raw suppliers

1-Bromo-4-(methoxymethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC=C(C=C1)Br

Technology Process of 1-Bromo-4-(methoxymethyl)benzene

There total 11 articles about 1-Bromo-4-(methoxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromobenzenemethanol (873-75-6) + methyl iodide (74-88-4) → 1-bromo-4-methoxymethylbenzene (1515-88-4)

Guidance literature:

4-bromobenzenemethanol; With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 - 20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; paraffin oil; at 20 ℃; for 15h;

DOI:10.1021/ol502583h

Reference yield: 98.0%

(dimethoxy)methylsilane (16881-77-9) + 4-bromo-benzaldehyde (1122-91-4) → 1-bromo-4-methoxymethylbenzene (1515-88-4)

Guidance literature:

(dimethoxy)methylsilane; 4-bromo-benzaldehyde; With dicarbonyl(pentamethylcyclopentadienyl)(4-methoxyphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 96.0%

sodium methylate (124-41-4) + 1-bromomethyl-4-bromobenzene (589-15-1) → 1-bromo-4-methoxymethylbenzene (1515-88-4)

Guidance literature:

In methanol; at 40 ℃; for 2h; Heating / reflux;

upstream raw materials:

sodium methylate

1-bromomethyl-4-bromobenzene

methanol

4-bromobenzenemethanol

Downstream raw materials:

1-(4-(methoxymethyl)phenyl)ethanone

4-bromobenzenecarbonitrile

benzyl methyl ether

(4-(methoxymethyl)phenyl)boronic acid

Refernces

• 1、 Arshady,Ledwith. "". . p. 819,821. Retrieved 1978.
• 2、 Bakos, Mária,Gy?m?re, ádám,Domján, Attila,Soós, Tibor. "Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones". supporting information. p. 5217 - 5221. Retrieved 2017/04/27.