N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

Base Information

• Chemical Name: N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide
• CAS No.: 1431534-08-5
• Molecular Formula: C₂₃H₂₁BrN₂O₃
• Molecular Weight: 453.335
• Mol file: 1431534-08-5.mol

Synonyms:N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

Chemical Property of N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

There total 2 articles about N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(benzyloxy)-3-bromopyridin-2-amine (941596-78-7) + 4-(cyclopropylmethoxy)benzoic acid (355391-05-8) → N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide (1431534-08-5)

Guidance literature:

4-(cyclopropylmethoxy)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 0.5h;

5-(benzyloxy)-3-bromopyridin-2-amine; With pyridine; at 20 ℃; for 0.333333h;

Reference yield:

5-phenylmethoxypyridin-2-amine (96166-00-6) → N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide (1431534-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / acetic acid / 2 h / 0 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

2.2: 0.33 h / 20 °C

With oxalyl dichloride; bromine; N,N-dimethyl-formamide; In tetrahydrofuran; acetic acid;

Reference yield:

N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide (1431534-08-5) → 6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[4,5-b]pyridine (1431534-09-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In tetrahydrofuran; water; at 70 ℃;

upstream raw materials:

5-phenylmethoxypyridin-2-amine

5-(benzyloxy)-3-bromopyridin-2-amine

4-(cyclopropylmethoxy)benzoic acid

Downstream raw materials:

6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[4,5-b]pyridine