2-carbomethoxy-3-(4-fluorophenyl)nortropane

Base Information

• Chemical Name: 2-carbomethoxy-3-(4-fluorophenyl)nortropane
• CAS No.: 127648-30-0
• Molecular Formula: C15H18 F N O2
• Molecular Weight: 263.312
• Mol file: 127648-30-0.mol

Synonyms:8-Azabicyclo[3.2.1]octane-2-carboxylicacid, 3-(4-fluorophenyl)-, methyl ester, [1R-(exo,exo)]-; Nor-b-CFT; O 375; RTI 142; RTI4229-142

Chemical Property of 2-carbomethoxy-3-(4-fluorophenyl)nortropane

Chemical Property:

• Vapor Pressure: 3.19E-05mmHg at 25°C
• Boiling Point: 355.2°Cat760mmHg
• PKA: 9.98±0.60(Predicted)
• Flash Point: 168.6°C
• PSA: 46.53000
• Density: 1.17g/cm³
• LogP: 2.81410

Purity/Quality:

99% ^*data from raw suppliers

(1R,2S,3S,5S)-Methyl 3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-carbomethoxy-3-(4-fluorophenyl)nortropane

There total 8 articles about 2-carbomethoxy-3-(4-fluorophenyl)nortropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(2,2,2-trichloroethylcarbamoyl)-2β-carbomethoxy-3β-(4'-fluorophenyl)nortropane (303733-95-1) → 2β-carbomethoxy-3β-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane (127648-30-0,131488-15-8)

Guidance literature:

Reference yield: 74.0%

2β-carbomethoxy-3β-(4-fluorophenyl)tropane (50370-59-7) → 2β-carbomethoxy-3β-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane (127648-30-0,131488-15-8)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; at 100 ℃; for 1h;

DOI:10.1021/jm00059a010

Reference yield:

methyl ecgonidine (50373-10-9) → 2β-carbomethoxy-3β-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane (127648-30-0,131488-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / diethyl ether / 1 h / -20 °C

2: 74 percent / α-chloroethyl chloroformate (ACE-Cl) / 1 h / 100 °C

With carbonochloridic acid 1-chloro-ethyl ester; In diethyl ether;

DOI:10.1021/jm00059a010

upstream raw materials:

N-(2,2,2-trichloroethylcarbamoyl)-2β-carbomethoxy-3β-(4'-fluorophenyl)nortropane

2β-carbomethoxy-3β-(4-fluorophenyl)tropane

ecgonidine

ecgonine

Downstream raw materials:

2β-carbomethoxy-3β-(4-fluorophenyl)-8-allylnortropane

N-[2-(3'-N'-propyl-(1R-3β-(4-fluorophenyl)-2β-methoxycarbonyltropane))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-2-aminoethanethiol

methyl 8-(4-fluorobut-2-yn-1-yl)-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

methyl 8-(((1R,2R)-2-(fluoromethyl)cyclopropyl)methyl)-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate