(2R,5R)-2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine

Base Information

• Chemical Name: (2R,5R)-2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine
• CAS No.: 123993-98-6
• Molecular Formula: C22H37 N O2 S
• Molecular Weight: 379.5997
• Mol file: 123993-98-6.mol

Synonyms:Pyrrolidine,2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]-, trans- (9CI); Pyrrolidine,2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]-, trans-(?à)-

Chemical Property of (2R,5R)-2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine

Chemical Property:

• Vapor Pressure: 1.59E-09mmHg at 25°C
• Boiling Point: 484.1°Cat760mmHg
• Flash Point: 246.6°C
• Density: 1.014g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,5R)-2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine

There total 6 articles about (2R,5R)-2-butyl-5-heptyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[5-butyl-1-(p-toluenesulfonyl)pyrrol-2-yl]heptan-1-one (1310050-87-3) → trans-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123993-98-6) + cis-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123994-01-4)

Guidance literature:

1-[5-butyl-1-(p-toluenesulfonyl)pyrrol-2-yl]heptan-1-one; With sodium cyanoborohydride; In dichloromethane; trifluoroacetic acid; at 0 - 20 ℃;

With palladium 10% on activated carbon; hydrogen; In methanol; for 3.5h; under 2068.65 Torr;

DOI:10.1039/c1ob05111c

Reference yield:

2-butyl-1-(p-toluenesulfonyl)pyrrole (1310050-85-1) → trans-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123993-98-6) + cis-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123994-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane; trifluoroacetic anhydride / 20 °C

2.1: sodium cyanoborohydride / dichloromethane; trifluoroacetic acid / 0 - 20 °C

2.2: 3.5 h / 2068.65 Torr

With sodium cyanoborohydride; In dichloromethane; trifluoroacetic acid; trifluoroacetic anhydride;

DOI:10.1039/c1ob05111c

Reference yield:

1-[1-(p-toluenesulfonyl)pyrrol-2-yl]butan-1-one (1310050-82-8) → trans-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123993-98-6) + cis-N-(p-tolylsulfonyl)-2-heptyl-5-butylpyrrolidine (123994-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol; dichloromethane / 0 - 20 °C

2.1: sodium cyanoborohydride / dichloromethane; acetic acid / 0 - 20 °C

3.1: dichloromethane; trifluoroacetic anhydride / 20 °C

4.1: sodium cyanoborohydride / dichloromethane; trifluoroacetic acid / 0 - 20 °C

4.2: 3.5 h / 2068.65 Torr

With sodium tetrahydroborate; sodium cyanoborohydride; In ethanol; dichloromethane; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride;

DOI:10.1039/c1ob05111c

upstream raw materials:

(E,E)-5,7-pentadecadiene

lithium acetate dihydrate

methanesulfonyl chloride

sodium p-toluenesulfonamide

Downstream raw materials:

(+/-)-trans-2-butyl-5-heptylpyrrolidine