Technology Process of 1-({[1-(4-ethoxyphenyl)cyclopropyl]methoxy}methyl)-3-phenoxybenzene
There total 6 articles about 1-({[1-(4-ethoxyphenyl)cyclopropyl]methoxy}methyl)-3-phenoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 14h;
Inert atmosphere;
DOI:10.3390/molecules24061023
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrabutylammomium bromide; potassium hydroxide / water / 24 h / 70 - 75 °C / Inert atmosphere
2: sodium hydroxide / water; methanol / 14 h / 100 - 105 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere
5: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / water; 1,4-dioxane / 100 - 115 °C / Inert atmosphere
6: potassium carbonate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydride; potassium carbonate; potassium hydroxide; sodium hydroxide; tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules24061023
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere
2: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / water; 1,4-dioxane / 100 - 115 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); sodium hydride; potassium carbonate; potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules24061023