2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile

Base Information

Chemical Name:2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile
CAS No.:96568-25-1
Molecular Formula:C13H8F2N2S
Molecular Weight:262.283
Hs Code.:
DSSTox Substance ID:DTXSID20541309
Wikidata:Q82417648

Synonyms:96568-25-1;SCHEMBL10652852;DTXSID20541309;2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile

Suppliers and Price of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:262.03762576
Heavy Atom Count:18
Complexity:322

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)SC2=C(C=C(C(=N2)F)C#N)F

Technology Process of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile

There total 4 articles about 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 96568-24-0
2-chloro-5-fluoro-6-(p-tolylthio)nicotinonitrile

: 96568-25-1
2,5-difluoro-6-(p-tolylthio)nicotinonitrile

Guidance literature:: With potassium fluoride; In dimethyl sulfoxide; at 130 - 135 ℃; for 1h;
DOI:10.1002/jhet.5570240520

Reference yield:

: 82671-02-1
2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

: 96568-25-1
2,5-difluoro-6-(p-tolylthio)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / KOH / ethanol / 2 h / Ambient temperature

2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C

With potassium fluoride; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1002/jhet.5570240520

Reference yield:

: 106-45-6
para-thiocresol

: 96568-25-1
2,5-difluoro-6-(p-tolylthio)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / KOH / ethanol / 2 h / Ambient temperature

2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C

With potassium fluoride; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1002/jhet.5570240520