2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide

Base Information

Chemical Name:2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide
CAS No.:108108-37-8
Molecular Formula:C13H10F2N2OS
Molecular Weight:280.298
Hs Code.:
DSSTox Substance ID:DTXSID50544520
Wikidata:Q82421639
Mol file:108108-37-8.mol

Synonyms:108108-37-8;DTXSID50544520;2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide

Suppliers and Price of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:280.04819044
Heavy Atom Count:19
Complexity:324

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)SC2=C(C=C(C(=N2)F)C(=O)N)F

Technology Process of 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide

There total 4 articles about 2,5-Difluoro-6-[(4-methylphenyl)sulfanyl]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 96568-25-1
2,5-difluoro-6-(p-tolylthio)nicotinonitrile

: 108108-37-8
2,5-difluoro-6-(p-tolylthio)nicotinamide

Guidance literature:: With sulfuric acid; at 50 - 55 ℃; for 1h;
DOI:10.1002/jhet.5570240520

Reference yield:

: 82671-02-1
2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

: 108108-37-8
2,5-difluoro-6-(p-tolylthio)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / KOH / ethanol / 2 h / Ambient temperature

2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C

3: 84 percent / conc. H₂SO₄ / 1 h / 50 - 55 °C

With potassium fluoride; potassium hydroxide; sulfuric acid; In ethanol; dimethyl sulfoxide;
DOI:10.1002/jhet.5570240520

Reference yield:

: 96568-24-0
2-chloro-5-fluoro-6-(p-tolylthio)nicotinonitrile

: 108108-37-8
2,5-difluoro-6-(p-tolylthio)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C

2: 84 percent / conc. H₂SO₄ / 1 h / 50 - 55 °C

With potassium fluoride; sulfuric acid; In dimethyl sulfoxide;
DOI:10.1002/jhet.5570240520