N-(1-benzylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

Base Information

• Chemical Name: N-(1-benzylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
• CAS No.: 73328-60-6
• Molecular Formula: C20H24ClN3O2
• Molecular Weight: 373.8765
• Mol file: 73328-60-6.mol

Synonyms:N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide;Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-(1-(phenylmethyl)-3-pyrrolidinyl);

Chemical Property of N-(1-benzylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

Chemical Property:

• Vapor Pressure: 1.58E-10mmHg at 25°C
• Boiling Point: 510.3°Cat760mmHg
• Flash Point: 262.4°C
• PSA: 57.09000
• Density: 1.25g/cm³
• LogP: 3.98030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-benzylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

There total 9 articles about N-(1-benzylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-(hydroxyimino)pyrrolidine (66832-28-8) → N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide (73328-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / H₂, ammonia / Raney nickel / methanol / 760 Torr

2: CH₂Cl₂ / 2 h / Ambient temperature

With ammonia; hydrogen; nickel; In methanol; dichloromethane;

DOI:10.1021/jm00142a019

Reference yield:

5-chloro-2-methoxy-4-(methylamino)benzoic acid (61694-98-2) → N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide (73328-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / -40 - -10 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1021/jm00142a019

Reference yield:

5-chloro-2-methoxy-4-(methylamino)benzoic acid methyl ester (78775-33-4) → N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide (73328-60-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 3.7percent aq. sodium hydroxide / 80 °C

2: triethylamine / CH₂Cl₂ / 0.5 h / -40 - -10 °C

3: CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; triethylamine; In dichloromethane;

DOI:10.1021/jm00142a019

upstream raw materials:

1-Benzyl-3-aminopyrrolidine

5-chloro-2-methoxy-4-(methylamino)benzoic acid

1-benzyl-3-(hydroxyimino)pyrrolidine

5-chloro-2-methoxy-4-(methylamino)benzoic acid methyl ester