(1R)-2-amino-1-(3-methylphenyl)ethan-1-ol

Base Information

Chemical Name:(1R)-2-amino-1-(3-methylphenyl)ethan-1-ol
CAS No.:97590-55-1
Molecular Formula:C9H13NO
Molecular Weight:151.208
Hs Code.:
DSSTox Substance ID:DTXSID101236697

Synonyms:97590-55-1;(1R)-2-amino-1-(3-methylphenyl)ethan-1-ol;SCHEMBL4598022;DTXSID101236697;EN300-1999401;Benzenemethanol, alpha-(aminomethyl)-3-methyl-, (R)-

Suppliers and Price of (1R)-2-amino-1-(3-methylphenyl)ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-2-amino-1-(3-methylphenyl)ethan-1-ol

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.099714038
Heavy Atom Count:11
Complexity:116

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C(CN)O
Isomeric SMILES:CC1=CC(=CC=C1)[C@H](CN)O

Technology Process of (1R)-2-amino-1-(3-methylphenyl)ethan-1-ol

There total 3 articles about (1R)-2-amino-1-(3-methylphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 704898-29-3,1195902-12-5,20697-03-4
3-methylstyrene oxide

: 1026230-99-8
(S)-2-amino-2-(m-tolyl)ethanol

: 97590-55-1
(R)-2-Amino-1-m-tolyl-ethanol

Guidance literature:: 3-methylstyrene oxide; With (R,R)-Jacobsen catalyst; water; In tetrahydrofuran; at 0 - 22 ℃; for 16h; Inert atmosphere;

With N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide; oxygen; In tetrahydrofuran; at 22 ℃; for 72h; Further stages; Inert atmosphere;
DOI:10.1021/acs.orglett.7b01886

Reference yield:

: 5955-74-8
m-toluoyl cyanide

: (S)-2-Amino-1-m-tolyl-ethanol

: 97590-55-1
(R)-2-Amino-1-m-tolyl-ethanol

Guidance literature:: With sodium tetrahydroborate; B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; cobalt(II) chloride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 2.) methanol;
DOI:10.1021/jo00217a053

Reference yield:

: 100-80-1
3-methylstyrene

: (S)-2-Amino-1-m-tolyl-ethanol

: 97590-55-1
(R)-2-Amino-1-m-tolyl-ethanol

Guidance literature:: With D-glucose; O-pivaloylhydroxylamine trifluoromethanesulfonate salt; catalase from Corynebacterium glutamicum; glucose oxidase Aspergillus niger; Rhodothermus marinus cytochrome c Y₄₄T, M₇₆Q, T₉₈L, M₉₉V, M₁₀₀S, T₁₀₁P and M₁₀₃G variant; water; In aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; for 2h; pH=8; enantioselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1002/anie.201812968