L-Alanine, 2-amino-2-oxoethyl ester (9CI)

Base Information

• Chemical Name: L-Alanine, 2-amino-2-oxoethyl ester (9CI)
• CAS No.: 98229-10-8
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.146
• Mol file: 98229-10-8.mol

Synonyms:Ala-OCAM;(S)-2-Amino-propionic acid carbamoylmethyl ester;

Chemical Property of L-Alanine, 2-amino-2-oxoethyl ester (9CI)

Chemical Property:

• PSA: 95.41000
• LogP: -0.23730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Alanine, 2-amino-2-oxoethyl ester (9CI)

There total 2 articles about L-Alanine, 2-amino-2-oxoethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-L-Ala carbamoylmethyl ester (4816-87-9) → L-Ala-CAM (98229-10-8)

Guidance literature:

With acetic acid; palladium on activated charcoal; In ethanol; water;

DOI:10.1016/S0040-4020(01)96451-8

Reference yield:

Boc-L-Ala-CAM (88830-50-6) → L-Ala-CAM (98229-10-8)

Guidance literature:

With hydrogenchloride; acetic acid;

DOI:10.1007/BF00811332

Reference yield: 26.0%

Cbz-Phe-OCH2CONH2 (4816-89-1) + L-Ala-CAM (98229-10-8) → Z-L-Phe-L-Ala-OCam (106556-08-5)

Guidance literature:

With Carbonate buffer; In N,N-dimethyl-formamide; for 0.0833333h; Ambient temperature; α-chymotrypsin;

DOI:10.1007/BF00811332

upstream raw materials:

Z-L-Ala carbamoylmethyl ester

Boc-L-Ala-CAM

Downstream raw materials:

BOC-L-Phe-L-Ala-CAM

Z-L-Phe-L-Ala-OCam

Z-Phe-Phe-Ala-OCAM

Refernces

• 1、 Martinez, Jean,Laur, Janine,Castro, Bertrand. "ON THE USE OF CARBOXAMIDOMETHYL ESTERS ( CAM ESTERS ) IN THE SYNTHESIS OF MODEL PEPTIDES. SCOPE AND LIMITATIONS". . p. 739 - 744. Retrieved 2007/10/02.