{Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol

Base Information

• Chemical Name: {Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol
• CAS No.: 98688-18-7
• Molecular Formula: C18H22O6
• Molecular Weight: 334.369
• DSSTox Substance ID: DTXSID30556429
• Wikidata: Q82437977
• Mol file: 98688-18-7.mol

Synonyms:98688-18-7;DTXSID30556429;{Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol

Chemical Property of {Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 334.14163842
• Heavy Atom Count: 24
• Complexity: 308

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)CO)OCCOC2=C(C=C(C=C2)CO)OC

Technology Process of {Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol

There total 5 articles about {Ethane-1,2-diylbis[oxy(3-methoxy-4,1-phenylene)]}dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-hydroxymethyl-2-methoxyphenol (498-00-0) + ethylene dibromide (106-93-4) → 1,2-bis(4-hydroxymethyl-2-methoxyphenoxy)ethane (98688-18-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1039/C39880000582

Reference yield: 26.0%

4-hydroxymethyl-2-methoxyphenol (498-00-0) + ethylene dibromide (106-93-4) → 1,2-bis(4-hydroxymethyl-2-methoxyphenoxy)ethane (98688-18-7) + (4-(2-bromoethoxy)-3-methoxyphenyl)methanol (98688-19-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 5h; Heating;

DOI:10.1021/ja00310a041

Reference yield:

vanillin (121-33-5,8014-42-4) → 1,2-bis(4-hydroxymethyl-2-methoxyphenoxy)ethane (98688-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanolic KOH

2: aluminium isopropylate

With potassium hydroxide; aluminum isopropoxide;

upstream raw materials:

Methyl isobutyl carbinol

4,4′-[ethane-1,2-diylbis(oxy)]bis(3-methoxy-benzaldehyde)

4-hydroxymethyl-2-methoxyphenol

ethylene dibromide

Downstream raw materials:

cryptophane-A