2,4,4-Pyrrolidinetricarboxylic acid, 1-acetyl-3-phenyl-, trimethyl ester, trans-

Base Information

• Chemical Name: 2,4,4-Pyrrolidinetricarboxylic acid, 1-acetyl-3-phenyl-, trimethyl ester, trans-
• CAS No.: 98806-92-9
• Molecular Formula: C₁₈H₂₁NO₇
• Molecular Weight: 363.367
• Mol file: 98806-92-9.mol

Synonyms:

Chemical Property of 2,4,4-Pyrrolidinetricarboxylic acid, 1-acetyl-3-phenyl-, trimethyl ester, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,4-Pyrrolidinetricarboxylic acid, 1-acetyl-3-phenyl-, trimethyl ester, trans-

There total 1 articles about 2,4,4-Pyrrolidinetricarboxylic acid, 1-acetyl-3-phenyl-, trimethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl 2-benzylidenepropanedioate (6626-84-2) + methyl N-(trimethylsilylmethyl)iminoacetate (98806-88-3) + acetyl chloride (75-36-5) → trimethyl N-acetyl-4-phenyl-2,3,3-pyrrolidinetricarboxylate (98806-93-0) + trimethyl N-acetyl-3-phenyl-2,4,4-pyrrolidinetricarboxylate (98806-92-9)

Guidance literature:

trifluoroacetic acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) HMPA, 1.5 h; 2.) pyridine, 1.5 h;

upstream raw materials:

dimethyl 2-benzylidenepropanedioate

methyl N-(trimethylsilylmethyl)iminoacetate

acetyl chloride

Refernces

• 1、 Imai, Nobuyuki,Terao, Yoshiyasu,Achiwa, Kazuo. "A NEW SYNTHETIC METHOD FOR PROLINE DERIVATIVES VIA THE AZOMETHINE YLIDE INTERMEDIATE GENERATED FROM METHYL N-(TRIMETHYLSILYLMETHYL)IMINOACETATE". . p. 1107 - 1110. Retrieved 2007/10/02.