Dimethyl benzylidenemalonate

Base Information

• Chemical Name: Dimethyl benzylidenemalonate
• CAS No.: 6626-84-2
• Molecular Formula: C12H12O4
• Molecular Weight: 220.225
• Hs Code.: 2917399090
• Mol file: 6626-84-2.mol

Synonyms:Malonic acid, benzylidene-, dimethyl ester;Dimethyl benzylidenemalonate;Propanedioic acid, (phenylmethylene)-, dimethyl ester;

Chemical Property of Dimethyl benzylidenemalonate

Chemical Property:

• Vapor Pressure: 0.00326mmHg at 25°C
• Melting Point: 27-28 °C
• Refractive Index: 1.549
• Boiling Point: 282.9°C at 760 mmHg
• Flash Point: 134°C
• PSA: 52.60000
• Density: 1.179g/cm³
• LogP: 1.41600

Purity/Quality:

98%,99%, ^*data from raw suppliers

dimethyl2-benzylidenepropanedioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl benzylidenemalonate

There total 34 articles about Dimethyl benzylidenemalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzaldehyde (100-52-7) + malonic acid dimethyl ester (108-59-8) → dimethyl 2-benzylidenepropanedioate (6626-84-2)

Guidance literature:

With rac-Pro-OH; In dimethyl sulfoxide; at 20 ℃; for 16h;

DOI:10.1081/SCC-120018782

Reference yield: 98.0%

dimethyl diazomalonate (6773-29-1) + benzaldehyde (100-52-7) → dimethyl 2-benzylidenepropanedioate (6626-84-2)

Guidance literature:

With tributylstibine; copper(l) iodide; In benzene; at 70 ℃; for 4h; other catalysts and trapping reagents; other substrates;

DOI:10.1016/S0040-4039(00)97988-7

Reference yield: 88.0%

N-benzoyl-N-methylaminoacetonitrile (36800-79-0) + malonic acid dimethyl ester (108-59-8) → dimethyl 2-benzylidenepropanedioate (6626-84-2)

Guidance literature:

N-benzoyl-N-methylaminoacetonitrile; With ithium diisobutyl-isopropoxyaluminumhydride; titanium tetrachloride; In tetrahydrofuran; at 0 ℃; for 1.16667h;

malonic acid dimethyl ester; With sodium hydride; at 0 ℃; for 0.5h;

DOI:10.1007/s11426-019-9586-3

upstream raw materials:

benzaldehyde

malonic acid dimethyl ester

Benzyl-methyl-sulfonium-bis-methoxycarbonylmethylid

methanol

Downstream raw materials:

dimethyl 2-(phenyl(phenylamino)methyl)malonate

methyl (S)-(-)-5-oxo-3-phenylhexanoate

(R)-methyl 5-oxo-3-phenylhexanoate

4-phenyl-4,5-dihydro-pyrazole-3,3-dicarboxylic acid dimethyl ester

Refernces

• 1、 Unaleroglu, Canan,Yazici, Arife. "Gadolinium triflate catalyzed alkylation of pyrroles: efficient synthesis of 3-oxo-2,3-dihydro-1H-pyrrolizine derivatives". . p. 5608 - 5613. Retrieved 2007.
• 2、 Johari, Suzaimi,Zaharani, Lia,Gorjian, Hayedeh,Johan, Mohd R.,Khaligh, Nader G.. "A novel sublimable organic salt: Synthesis, characterization, thermal behavior, and catalytic activity for the synthesis of arylidene, heteroarylidene, and alkylidene malonates". . p. 361 - 377. Retrieved 2021/09/18.
• 3、 Sang, Ji-Wei,Xie, Ming-Sheng,Wang, Man-Man,Qu, Gui-Rong,Guo, Hai-Ming. "Chemo- And regioselective ring-opening of donor-acceptor oxiranes with: N -heteroaromatics". supporting information. p. 4552 - 4555. Retrieved 2021/05/17.