Drostanolone

Base Information

• Chemical Name: Drostanolone
• CAS No.: 58-19-5
• Molecular Formula: C20H32 O2
• Molecular Weight: 304.473
• Hs Code.: 2937290015
• European Community (EC) Number: 200-367-9
• NSC Number: 26198
• UNII: 7DR7H00HDT
• DSSTox Substance ID: DTXSID6022971
• Nikkaji Number: J10.681J
• Wikipedia: Drostanolone
• Wikidata: Q422343
• NCI Thesaurus Code: C1076
• Metabolomics Workbench ID: 43137
• ChEMBL ID: CHEMBL1582
• Mol file: 58-19-5.mol

Synonyms:17 beta-hydroxy-2 alpha-methyl-5 alpha-androstan-3-one;dromostanolone;dromostanolone, (5alpha,17beta)-isomer;drostanolon;drostanolone;methalone;prometholone

Chemical Property of Drostanolone

Chemical Property:

• Vapor Pressure: 7.98E-09mmHg at 25°C
• Melting Point: 149-153oC
• Boiling Point: 420.3°Cat760mmHg
• PKA: 15.09±0.70(Predicted)
• Flash Point: 179.4°C
• PSA: 37.30000
• Density: 1.058g/cm³
• LogP: 4.20510
• Storage Temp.: Refrigerator
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 304.240230259
• Heavy Atom Count: 22
• Complexity: 486

Purity/Quality:

98% ^*data from raw suppliers

Drostanolone ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2(C(CCC3C2CCC4(C3CCC4O)C)CC1=O)C
• Isomeric SMILES: C[C@@H]1C[C@]2([C@@H](CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C)CC1=O)C
• Uses: Synthetic estrogen antagonist. Antineoplastic. Controlled substance.
• Therapeutic Function: Cancer chemotherapy

Technology Process of Drostanolone

There total 20 articles about Drostanolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxymethylene-17β-hydroxy-5α-androstan-3-one (4033-95-8) → dromostanolone (58-19-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 10 ℃; for 16h; under 760.051 Torr;

Reference yield:

→ dromostanolone (58-19-5)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01511a040

Reference yield:

3,3-ethanediyldioxy-2α-methyl-androst-5-en-17β-ol (19990-45-5) → dromostanolone (58-19-5)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation_.beim anschliessenden Erwaermen mit wss. HCl;

DOI:10.1021/ja01511a040

upstream raw materials:

3,3-ethanediyldioxy-2α-methyl-androst-5-en-17β-ol

dromostanolone propionate

2α,3-Cyclopropano-5α-androstan-3β,17β-diol

3β-Methoxy-2α,3α-methylene-5α-androstan-17β-ol acetate

Downstream raw materials:

2α-methyl-17β-(3-phenyl-propionyloxy)-5α-androstan-3-one

17β-acetoxy-2α-methyl-5α-androstan-3-one

2α-Methyl-5α-androstan-3,17-dion

Refernces

• 1、 -. "NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF". . . Retrieved 2015/02/02.
• 2、 Marat, Kirk,Templeton, John F.,Gupta, R. K.,Kumar, Sashi V. P.. "Ring A Conformation in Steroids 2 -NMR Study of C-2 Monomethyl- and Dimethyl-Substituted 5α-Androstan-3-ones". . p. 730 - 733. Retrieved 2007/10/02.