MK-1220

Base Information

• Chemical Name: MK-1220
• CAS No.: 924270-31-5
• Molecular Formula: C₄₀H₅₃N₅O₉S
• Molecular Weight: 779.955

Synonyms:MK-1220;JXYSYDXTCQGOTL-QXURCLOISA-N

Chemical Property of MK-1220

Chemical Property:

• PSA: 190.71000
• LogP: 6.42790

Purity/Quality:

95% ^*data from raw suppliers

MK-1220 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MK-1220

There total 6 articles about MK-1220 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid (914841-18-2) → C40H53N5O9S (924270-31-5)

Guidance literature:

Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

2: Zhan 1b metathesis catalyst / dichloromethane

3: palladium on carbon; hydrogen

4: ethanol; lithium hydroxide / tetrahydrofuran

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With ethanol; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

Reference yield:

C17H19BrN2O4 (924365-09-3) → C40H53N5O9S (924270-31-5)

Guidance literature:

Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

2: Zhan 1b metathesis catalyst / dichloromethane

3: palladium on carbon; hydrogen

4: ethanol; lithium hydroxide / tetrahydrofuran

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With ethanol; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

Reference yield:

ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-L-prolinate (924271-88-5) → C40H53N5O9S (924270-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Zhan 1b metathesis catalyst / dichloromethane

2: palladium on carbon; hydrogen

3: ethanol; lithium hydroxide / tetrahydrofuran

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With ethanol; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

upstream raw materials:

(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride

(3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

C₁₇H₁₉BrN₂O₄

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid

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