Milveterol

Base Information

Chemical Name:Milveterol
CAS No.:652990-07-3
Molecular Formula:C25H29N3O4
Molecular Weight:435.523
Hs Code.:
UNII:LGY1VQ9622
DSSTox Substance ID:DTXSID30215640
Wikidata:Q27282977
NCI Thesaurus Code:C77935
Pharos Ligand ID:PVDGBMG4US53
ChEMBL ID:CHEMBL1940832
Mol file:652990-07-3.mol

Synonyms:Milveterol;652990-07-3;Milveterol [INN];UNII-LGY1VQ9622;GSK159797;LGY1VQ9622;N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[2-[4-[[(2R)-2-hydroxy-2-phenylethyl]amino]phenyl]ethylamino]ethyl]phenyl]formamide;N-(2-Hydroxy-5-((R)-1-hydroxy-2-((4-(((R)-2-hydroxy-2-phenylethyl)amino)phenethyl)amino)ethyl)phenyl)formamide;starbld0040681;D02KMG;SCHEMBL265694;CHEMBL1940832;DTXSID30215640;BMKINZUHKYLSKI-DQEYMECFSA-N;BDBM50419652;TD3327;GSK 159797;Q27282977;FORMAMIDE, N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-((2-(4-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)PHENYL)ETHYL)AMINO)ETHYL)PHENYL)-;N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-((2-(4-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)PHENYL)ETHYL)AMINO)ETHYL)PHENYL)FORMAMIDE;N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine

Suppliers and Price of Milveterol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MILVETEROL 95.00%
5MG
$ 498.43

Total 11 raw suppliers

Chemical Property of Milveterol

Chemical Property:

PSA：117.34000
LogP:4.08510
XLogP3:2.3
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:435.21580641
Heavy Atom Count:32
Complexity:523

Purity/Quality:

99% ^*data from raw suppliers

MILVETEROL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
Isomeric SMILES:C1=CC=C(C=C1)[C@H](CNC2=CC=C(C=C2)CCNC[C@@H](C3=CC(=C(C=C3)O)NC=O)O)O
Recent ClinicalTrials:Study Investigating Repeat Doses Of A New Medication (GSK159797) In Asthmatic Patients

Technology Process of Milveterol

There total 6 articles about Milveterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 652990-10-8
N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-benzyloxyphenyl)ethylamine

: 652990-07-3
milveterol

Guidance literature:: N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-benzyloxyphenyl)ethylamine; With darco G-60; In ethanol; at 50 ℃; for 0.333333h;

With hydrogen; palladium 10% on activated carbon; In ethanol; for 10h; under 1551.49 Torr;

Reference yield:

: 13472-00-9
p-Aminophenethylamine

: 652990-07-3
milveterol

Guidance literature:: Multi-step reaction with 5 steps

1: toluene

2: sodium tetrahydroborate / tetrahydrofuran; methanol

3: n-butyllithium / tetrahydrofuran / -78 °C

4: toluene / Reflux

5: palladium 10% on activated carbon; hydrogen / ethanol

With sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1016/j.bmcl.2011.11.072

Reference yield:

: 344466-47-3
C₂₂H₂₄N₂

: 652990-07-3
milveterol

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: toluene / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol

With n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmcl.2011.11.072