PF-04457845

Base Information

Chemical Name:PF-04457845
CAS No.:1020315-31-4
Molecular Formula:C23H20F3N5O2
Molecular Weight:455.439
Hs Code.:
Mol file:1020315-31-4.mol

Synonyms:PF-04457845;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide

Suppliers and Price of PF-04457845

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PF04457845
1mg
$ 45.00

Tocris
PF04457845 ≥98%(HPLC)
25
$ 301.00

Tocris
PF04457845 ≥98%(HPLC)
5
$ 77.00

DC Chemicals
PF-04457845 >98%
250 mg
$ 800.00

Crysdot
PF-04457845 98+%
25mg
$ 326.00

Crysdot
PF-04457845 98+%
50mg
$ 580.00

ChemScene
PF-04457845 99.37%
100mg
$ 540.00

ChemScene
PF-04457845 99.37%
10mg
$ 95.00

ChemScene
PF-04457845 99.37%
5mg
$ 55.00

ChemScene
PF-04457845 99.37%
50mg
$ 300.00

Total 26 raw suppliers

Chemical Property of PF-04457845

Chemical Property:

Boiling Point:687.0±55.0 °C(Predicted)
PKA:12.72±0.20(Predicted)
PSA：83.47000
Density:1.389±0.06 g/cm3(Predicted)
LogP:4.75380
Storage Temp.:room temp

Purity/Quality:

99%, ^*data from raw suppliers

PF04457845 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of PF-04457845

There total 7 articles about PF-04457845 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1020327-61-0
phenyl pyridazin-3-ylcarbamate

: 1020325-53-4
2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

: 1020315-31-4
PF-04457845

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 19h; Product distribution / selectivity;

Reference yield:

: 1020325-53-4
2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

: 76925-49-0
ethyl pyridazin-3-ylcarbamate

: 1020315-31-4
PF-04457845

Guidance literature:: With triethylamine; In acetonitrile; at 180 ℃; for 0.666667h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 1020325-30-7
2-[3-(chIoromethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 1020315-31-4
PF-04457845

Guidance literature:: Multi-step reaction with 4 steps

1: 16 h / 130 °C

2: potassium tert-butylate / tetrahydrofuran

3: hydrogenchloride; water / 1,4-dioxane

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

With hydrogenchloride; potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ml100190t