2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

Base Information

Chemical Name:2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride
CAS No.:1020325-53-4
Molecular Formula:C₁₈H₁₇F₃N₂O*ClH
Molecular Weight:370.802
Hs Code.:

Synonyms:2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

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Chemical Property of 2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

Chemical Property:

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Technology Process of 2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

There total 6 articles about 2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1020325-45-4
4-[3-(5-trifluoromethyl-pyridin-2-yloxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester

: 1020325-53-4
2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at -5 - 22 ℃; for 17.33h; Product distribution / selectivity;

Reference yield:

: 1020325-30-7
2-[3-(chIoromethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 1020325-53-4
2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 16 h / 130 °C

2: potassium tert-butylate / tetrahydrofuran

3: hydrogenchloride; water / 1,4-dioxane

With hydrogenchloride; potassium tert-butylate; water; In tetrahydrofuran; 1,4-dioxane; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ml100190t

Reference yield:

: 1020325-38-5
2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 1020325-53-4
2-(3-piperidin-4-ylidenemethyl-phenoxy)-5-trifluoromethyl-pyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran

2: hydrogenchloride; water / 1,4-dioxane

With hydrogenchloride; potassium tert-butylate; water; In tetrahydrofuran; 1,4-dioxane; 1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ml100190t