KU-60019

Base Information

Chemical Name:KU-60019
CAS No.:925701-49-1
Molecular Formula:C₃₀H₃₃N₃O₅S
Molecular Weight:547.675
Hs Code.:
UNII:IAN358A69K
ChEMBL ID:CHEMBL2140173
DSSTox Substance ID:DTXSID00580453
Nikkaji Number:J3.354.684J
Pharos Ligand ID:K8X1NR9QR41D
Wikidata:Q27894826
Mol file:925701-49-1.mol

Synonyms:2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;KU 60019;KU-60019;KU60019

Suppliers and Price of KU-60019

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
KU 60019
100mg
$ 1932.00

Cayman Chemical
Ku-60019 ≥98%
10mg
$ 175.00

Cayman Chemical
Ku-60019 ≥98%
5mg
$ 105.00

Cayman Chemical
Ku-60019 ≥98%
25mg
$ 350.00

Cayman Chemical
Ku-60019 ≥98%
1mg
$ 35.00

Biorbyt Ltd
KU-60019 >98%
1000 mg
$ 3282.70

Biorbyt Ltd
KU-60019 >98%
250 mg
$ 1654.10

Biorbyt Ltd
KU-60019 >98%
100 mg
$ 912.90

Arctom
KU-60019 ≥98%
10mg
$ 208.00

ApexBio Technology
KU-60019
50mg
$ 300.00

Total 39 raw suppliers

Chemical Property of KU-60019

Chemical Property:

Boiling Point:786.6 °C at 760 mmHg
Flash Point:429.5 °C
PSA：109.55000
Density:1.314g/cm³
LogP:4.32240
Storage Temp.:-20°C
Solubility.:≥27.4 mg/mL in DMSO; insoluble in H2O; ≥51.2 mg/mL in EtOH
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:547.21409234
Heavy Atom Count:39
Complexity:972

Purity/Quality:

99%, ^*data from raw suppliers

KU 60019 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6
Isomeric SMILES:C[C@@H]1CN(C[C@@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6
Description KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
Uses KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.

Technology Process of KU-60019

There total 1 articles about KU-60019 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cis-2,6-dimethylmorpholine

: 587871-49-6
2-(7-amino-9H-thioxanthen-4-yl)-6-morpholin-4-yl-pyran-4-one

: 79-04-9
chloroacetyl chloride

: 925701-46-8,925701-49-1
(2R,6S-rel)-2,6-dimethyl-N-[5[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide

Guidance literature:: 2-(7-amino-9H-thioxanthen-4-yl)-6-morpholin-4-yl-pyran-4-one; chloroacetyl chloride; With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 1.5h;

cis-2,6-dimethylmorpholine; In N,N-dimethyl acetamide; at 20 ℃; Product distribution / selectivity;