Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate
CAS No.:192940-81-1
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:
DSSTox Substance ID:DTXSID70594108

Synonyms:192940-81-1;TERT-BUTYL 3-(2-HYDROXYETHYL)-3-PHENYLPYRROLIDINE-1-CARBOXYLATE;SCHEMBL7000547;DTXSID70594108;QYEDCSBAKVBMRG-UHFFFAOYSA-N;AKOS015904190;TERT-BUTYL 3-(2-HYDROXYETHYL)-3-PHENYLPYRROLIDINE-1-CARBOXYLATE,95+%;A813620;1-t-butoxycarbonyl-3-phenyl-3-(2-hydroxyethyl)pyrrolidine;1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine;tert-butyl 3-(2-hydroxyethyl)-3-phenyl-pyrrolidine-1-carboxylate

Suppliers and Price of Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate

Chemical Property:

Vapor Pressure:2.03E-07mmHg at 25°C
Boiling Point:408.9°C at 760 mmHg
Flash Point:201.1°C
Density:1.101g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:291.18344366
Heavy Atom Count:21
Complexity:358

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C1)(CCO)C2=CC=CC=C2

Technology Process of Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate

There total 3 articles about Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 52423-63-9
2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol

: 24424-99-5
di-tert-butyl dicarbonate

: 192940-81-1,209667-56-1
1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2009.11.072

Reference yield:

: 52423-63-9
2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol

: 1133464-33-1,178371-24-9,178371-26-1
(+)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine (R,R)-di-p-anisoyltartaric acid salt

: 24424-99-5
di-tert-butyl dicarbonate

: 192940-81-1,209667-56-1
1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 140-29-4
phenylacetonitrile

: 192940-81-1,209667-56-1
1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 - 10 °C

1.2: 24 h / -78 - 20 °C

2.1: hydrogen; nickel / 48 h / 20 °C / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 20 - 70 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; nickel; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; water;