2-(3-Phenylpyrrolidin-3-yl)ethanol

Base Information

• Chemical Name: 2-(3-Phenylpyrrolidin-3-yl)ethanol
• CAS No.: 52423-63-9
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50594101
• Mol file: 52423-63-9.mol

Synonyms:2-(3-phenylpyrrolidin-3-yl)ethanol;52423-63-9;2-(3-Phenylpyrrolidin-3-yl)ethan-1-ol;SCHEMBL6996455;DTXSID50594101;JBGZJQULYGMJGT-UHFFFAOYSA-N;2-(3-Phenyl-3-pyrrolidinyl)ethanol;AKOS015919064;2-(3-phenyl-pyrrolidin-3-yl)-ethanol;3-phenyl-3-(2-hydroxyethyl)pyrrolidine;3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine;DB-013346;A7684;2-(3-Phenyl-3-pyrrolidinyl)ethanol, AldrichCPR

Chemical Property of 2-(3-Phenylpyrrolidin-3-yl)ethanol

Chemical Property:

• Vapor Pressure: 7.45E-05mmHg at 25°C
• Melting Point: 111 °C
• Refractive Index: 1.537
• Boiling Point: 328.8 °C at 760 mmHg
• Flash Point: 128.3 °C
• PSA: 32.26000
• Density: 1.048 g/cm³
• LogP: 1.62890
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

97% ^*data from raw suppliers

2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1(CCO)C2=CC=CC=C2

Technology Process of 2-(3-Phenylpyrrolidin-3-yl)ethanol

There total 9 articles about 2-(3-Phenylpyrrolidin-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C13H15NO3 (1014702-72-7) → 2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol (52423-63-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 - 70 ℃;

Reference yield: 78.0%

[3-phenyl-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester (40877-31-4) → 2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol (52423-63-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/j.bmcl.2009.11.072

Reference yield:

Rochelle's salt (304-59-6) + [3-phenyl-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester (40877-31-4) → 2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol (52423-63-9)

Guidance literature:

With sodium sulfate; In tetrahydrofuran; diethyl ether;

upstream raw materials:

Rochelle's salt

[3-phenyl-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester

sodium sulfate

water

Downstream raw materials:

(+)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine (R,R)-di-p-anisoyltartaric acid salt

1-(3,4,5-trimethoxy-benzoyl)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine

1-(2,3,4-trimethoxybenzoyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine

1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine