52423-63-9

Basic information

• Product Name: 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL
• Synonyms: 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL;3-Phenyl-3-pyrrolidineethanol;2-(3-phenylpyrrolidin-3-yl)ethan-1-ol
• CAS NO: 52423-63-9
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.272
• Mol File: 52423-63-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 111℃
• Boiling Point: 328.8 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.048
• Vapor Pressure: 7.45E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL(52423-63-9)
• EPA Substance Registry System: 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL(52423-63-9)

Safety Data

• Hazardous Substances Data: 52423-63-9(Hazardous Substances Data)

Usage

General Description

2-(3-Phenylpyrrolidin-3-yl)ethanol is a chemical compound with the molecular formula C14H19NO. It is a synthetic organic compound that belongs to the class of pyrrolidine derivatives, which are commonly used in medicinal chemistry and drug development. 2-(3-PHENYLPYRROLIDIN-3-YL)ETHANOL is a secondary alcohol, with a pyrrolidine ring attached to a phenyl group and an ethanolic tail. It may have potential applications in the pharmaceutical industry, particularly in the development of new drugs targeting the central nervous system. As with any chemical compound, 2-(3-Phenylpyrrolidin-3-yl)ethanol should be handled and used with caution, following proper safety guidelines and regulations.

InChI:InChI=1/C12H17NO/c14-9-7-12(6-8-13-10-12)11-4-2-1-3-5-11/h1-5,13-14H,6-10H2

Upstream product

• 304-59-6 Rochelle's salt 
• 40877-31-4 [3-phenyl-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester 
• 140-29-4 phenylacetonitrile 
• 40877-30-3 3-cyano-3-phenyl-pentanedioic acid diethyl ester 
• 7732-18-5 water 
• 7757-82-6 sodium sulfate 
• 1014702-72-7 C₁₃H₁₅NO₃ 

Downstream Products

• 1133464-33-1 (+)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine (R,R)-di-p-anisoyltartaric acid salt 
• 178371-22-7 1-(3,4,5-trimethoxy-benzoyl)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine 
• 370559-34-5 1-(2,3,4-trimethoxybenzoyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine 
• 192940-81-1 1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine 
• 1102346-51-9 1-(3,4,5-trimethoxy-benzoyl)-3-[2-[4-[1-(5-methylfur-2-ylmethyl)-1H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-phenyl-pyrrolidine 
• 178371-14-7 1-(3,4,5-trimethoxy-benzoyl)-3-[2-[4-[1H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-phenyl-pyrrolidine 
• 178371-29-4 1-(3,4,5-trimethoxybenzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine 
• 1014701-47-3 {5-[2-(1-cyclopenanecarbonyl-3-phenyl-pyrrolidin-1-yl)-ethyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-[3,5-dimethyl-1-(5-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-methanone 
• 1014702-79-4 C₃₅H₄₃F₃N₆O₃ 

Relevant articles and documents

Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles

Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability.

SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT ALLERGIC DISEASES

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4] diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted piperidines useful for the treatment of allergic diseases

The present invention relates to novel substituted piperidine derivatives of the formula STR1stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.