1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione

Base Information

• Chemical Name: 1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione
• CAS No.: 127801-83-6
• Molecular Formula: C9H6N4O2
• Molecular Weight: 202.17
• Hs Code.: 2933990090
• Mol file: 127801-83-6.mol

Synonyms:pyridazinodequinazolinedione;1H-pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione;EE-0707;

Chemical Property of 1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione

Chemical Property:

• Melting Point: >320°
• PSA: 94.40000
• LogP: 0.09270

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione

There total 4 articles about 1H-Pyridazino[3,4,5-de]quinazoline-3,8(2H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-carbomethoxy-2,4-dihydroxyquinazoline (127801-84-7) → 2,6-dihydroxy-4H-pyridazino<3,4,5-de>quinazoline (127801-83-6)

Guidance literature:

With hydrazine; for 3h; Heating;

DOI:10.1002/jhet.5570260667

Reference yield:

dimethyl 3-nitrophthalate (13365-26-9) → 2,6-dihydroxy-4H-pyridazino<3,4,5-de>quinazoline (127801-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

2: 100 percent / acetic acid / 0.5 h / Heating

3: 87 percent / hydrazine / 3 h / Heating

With acetic acid; hydrazine; cyclohexene; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570260667

Reference yield:

3-nitrophthalic acid (603-11-2) → 2,6-dihydroxy-4H-pyridazino<3,4,5-de>quinazoline (127801-83-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / diethyl ether

2: 100 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

3: 100 percent / acetic acid / 0.5 h / Heating

4: 87 percent / hydrazine / 3 h / Heating

With acetic acid; hydrazine; cyclohexene; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1002/jhet.5570260667

upstream raw materials:

5-carbomethoxy-2,4-dihydroxyquinazoline

dimethyl 3-nitrophthalate

3-nitrophthalic acid

dimethyl 3-aminophthalate