Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate

Base Information

• Chemical Name: Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate
• CAS No.: 127801-84-7
• Molecular Formula: C10H8N2O4
• Molecular Weight: 220
• Hs Code.: 2933990090
• Mol file: 127801-84-7.mol

Synonyms:Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate

Chemical Property of Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate

Chemical Property:

• PSA: 92.02000
• LogP: 0.00300

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate

There total 4 articles about Methyl 2,4-dioxo-1,2,3,4-tetrahydro-5-quinazolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium cyanate (590-28-3) + dimethyl 3-aminophthalate (34529-06-1) → 5-carbomethoxy-2,4-dihydroxyquinazoline (127801-84-7)

Guidance literature:

With acetic acid; for 0.5h; Heating;

DOI:10.1002/jhet.5570260667

Reference yield:

dimethyl 3-nitrophthalate (13365-26-9) → 5-carbomethoxy-2,4-dihydroxyquinazoline (127801-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

2: 100 percent / acetic acid / 0.5 h / Heating

With acetic acid; cyclohexene; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570260667

Reference yield:

3-nitrophthalic acid (603-11-2) → 5-carbomethoxy-2,4-dihydroxyquinazoline (127801-84-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / diethyl ether

2: 100 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

3: 100 percent / acetic acid / 0.5 h / Heating

With acetic acid; cyclohexene; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1002/jhet.5570260667

upstream raw materials:

potassium cyanate

dimethyl 3-aminophthalate

dimethyl 3-nitrophthalate

3-nitrophthalic acid

Downstream raw materials:

2,6-dihydroxy-4H-pyridazino<3,4,5-de>quinazoline

Refernces