Lansoprazole sulfone N-oxide

Base Information

• Chemical Name: Lansoprazole sulfone N-oxide
• CAS No.: 953787-54-7
• Molecular Formula: C₁₆H₁₄F₃N₃O₄S
• Molecular Weight: 401.366
• Mol file: 953787-54-7.mol

Synonyms:2-[[[3-Methyl-1-oxido-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulfonyl]-1H-benzimidazole;

Chemical Property of Lansoprazole sulfone N-oxide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 224-226°C
• Refractive Index: 1.608
• Boiling Point: 654.605 °C at 760 mmHg
• Flash Point: 349.693 °C
• PSA: 105.89000
• Density: 1.532 g/cm³
• LogP: 4.29560
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

LansoprazoleSulfoneN-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Lansoprazole.

Technology Process of Lansoprazole sulfone N-oxide

There total 5 articles about Lansoprazole sulfone N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

lansoprazole sulfide (103577-40-8) → 2-[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole (953787-54-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; cooling;

DOI:10.1080/00397910802162934

Reference yield:

2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole (163119-30-0) → 2-[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole (953787-54-7) + lansoprazole N-oxide (213476-12-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2.66667h;

DOI:10.1080/00397910701470693

Reference yield:

lansoprasole (103577-45-3) → 2-[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole (953787-54-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/jms.3949

upstream raw materials:

2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

2-chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-1-oxide

lansoprazole sulfide

lansoprasole

Refernces

• 1、 Reddy, Ganta Madhusudhan,Mukkanti,Kumar, T. Laxmi,Babu, J. Moses,Reddy, Padi Pratap. "Synthesis and characterization of metabolites and potential impurities of lansoprazole, an antiulcerative drug". . p. 3477 - 3489. Retrieved 2008/12/23.