tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate
CAS No.:864359-18-2
Molecular Formula:C17H25NO3
Molecular Weight:291.39
Hs Code.:

Synonyms:4-(4-hydroxymethyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate;4-(4-hydroxymethylphenyl)piperidine-1-carboxylic acid tert-butyl ester;t-butyl 4-[4-(hydroxymethyl)phenyl]piperidin-1-carboxylate;

Suppliers and Price of tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
4-(4-Hydroxymethyl-phenyl)-piperidine-1-carboxylicacidtert-butylester 98%
5g
$ 2990.00

J&W Pharmlab
4-(4-Hydroxymethyl-phenyl)-piperidine-1-carboxylicacidtert-butylester 98%
1g
$ 880.00

Total 7 raw suppliers

Chemical Property of tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Chemical Property:

PSA：49.77000
LogP:3.23130

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Hydroxymethyl-phenyl)-piperidine-1-carboxylicacidtert-butylester 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 149353-75-3
4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

: 864359-18-2
tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Guidance literature:: 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid; With borane-THF; In tetrahydrofuran; at 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 69.0%

: 206446-48-2
tert-butyl 4-[4-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate

: 864359-18-2
tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 69.0%

: 873-75-6
4-bromobenzenemethanol

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 864359-18-2
tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Guidance literature:: 4-bromobenzenemethanol; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); palladium 10% on activated carbon; In 1,4-dioxane; water; at 80 ℃; for 4h; Sealed tube; Inert atmosphere;

With ammonium bicarbonate; In methanol; at 18 ℃; for 16h;
DOI:10.1039/c7cc08670a