tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate
• CAS No.: 206446-48-2
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428
• Mol file: 206446-48-2.mol

Synonyms:tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 439.5±45.0 °C(Predicted)
• PKA: -1.82±0.40(Predicted)
• PSA: 55.84000
• Density: 1.099±0.06 g/cm3(Predicted)
• LogP: 3.91570

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-(ethoxycarbonyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ethyl 4-bromobenzoate (5798-75-4) + tert-butyl 4-bromo-1-piperidinecarboxylate (180695-79-8) → tert-butyl 4-[4-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate (206446-48-2)

Guidance literature:

With potassium hexafluorophosphate; bis(1,3-bis((4-methyl-2-pyridyl)imino)isoindolinato)nickel(II); C₂₂H₁₉N₅NiO₂; In N,N-dimethyl acetamide; at 20 ℃; Inert atmosphere; Electrolysis; Sealed tube;

DOI:10.1021/jacs.0c01475

Reference yield: 82.0%

Ethyl 4-bromobenzoate (5798-75-4) + tert-butyl 4-iodopiperidine-1-carboxylate (301673-14-3) → tert-butyl 4-[4-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate (206446-48-2)

Guidance literature:

With copper(I) oxide; 3,4,7,8-Tetramethyl-o-phenanthrolin; nickel(II) acetate tetrahydrate; zinc; In 2-methyltetrahydrofuran; water; at 45 ℃; for 16h; chemoselective reaction; Glovebox;

DOI:10.1039/d1cc02885e

Reference yield: 65.0%

4-(4-ethoxycarbonylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1240969-31-6) → tert-butyl 4-[4-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate (206446-48-2)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In methanol; for 3h; High pressure;

DOI:10.1021/acsmedchemlett.6b00360

upstream raw materials:

4-iodobenzoic acid ethyl ester

tert-butyl 4-iodopiperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

4-HYDROXYPIPERIDINE