1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea

Base Information

Chemical Name:1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea
CAS No.:620960-26-1
Molecular Formula:C₁₇H₂₁F₆N₃S
Molecular Weight:413.43
Hs Code.:
European Community (EC) Number:811-865-6
ChEMBL ID:CHEMBL3746712
Nikkaji Number:J1.962.991K
Mol file:620960-26-1.mol

Synonyms:620960-26-1;1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea;1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea;1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea;C17H21F6N3S;1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea(R,R-TUC);MFCD09834839;1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea (R,R-TUC);1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-(-)-2-(dimethylamino)cyclohexyl)thiourea (R,R-TUC);916665-84-4;SCHEMBL812122;CHEMBL3746712;AMY23941;AKOS022184801;DS-3777;CS-0061697;CS-0093326;C75913;EN300-7416800;A868556;(r,r)-trans-1-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(n,n-dimethylamino)cyclohexyl]thiourea;1-[3,5-bis(trifluoromethy) phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea;1-[3,5-bis(trifluoromethy)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea;1-[3 pound not5-Bis(trifluoromethyl)phenyl]-3-[(1R pound not2R)-2-(dimethylamino)cyclohexyl]thiourea;1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea, AldrichCPR

Suppliers and Price of 1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
1g
$ 152.00

Strem Chemicals
1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea (R,R-TUC)
1g
$ 127.00

Strem Chemicals
1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea (R,R-TUC)
250mg
$ 42.00

Crysdot
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
250mg
$ 83.00

Crysdot
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
1g
$ 208.00

Crysdot
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
5g
$ 644.00

Crysdot
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
10g
$ 1012.00

Crysdot
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
25g
$ 1935.00

Chemenu
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
25g
$ 1823.00

Chemenu
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea 96%
10g
$ 954.00

Total 24 raw suppliers

Chemical Property of 1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea

Chemical Property:

Melting Point:87-88°C
Boiling Point:380.8±52.0 °C(Predicted)
PKA:11.76±0.70(Predicted)
PSA：59.39000
Density:1.33±0.1 g/cm3(Predicted)
LogP:5.34730
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:413.13603783
Heavy Atom Count:27
Complexity:486

Purity/Quality:

97% ^*data from raw suppliers

^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1CCCCC1NC(=S)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
Isomeric SMILES:CN(C)[C@@H]1CCCC[C@H]1NC(=S)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F

Technology Process of 1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea

There total 8 articles about 1-(3,5-Bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)cyclohexyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 860994-58-7
1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 620960-26-1
1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea

Guidance literature:: 1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; formaldehyd; In 1,2-dichloro-ethane; at 20 ℃; for 0.25h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 6h; Inert atmosphere;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; for 0.25h;
DOI:10.1002/adsc.201200558