(1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine

Base Information

• Chemical Name: (1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine
• CAS No.: 894493-95-9
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 29130000
• Mol file: 894493-95-9.mol

Synonyms:1,2-Cyclohexanediamine,N,N-dimethyl-, (1S,2S)- (9CI);(1S,2S)-N,N-Dimethylcyclohexane-1,2-diamine;

Chemical Property of (1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine

Chemical Property:

• Refractive Index: 1.49
• Boiling Point: 180.3 °C at 760 mmHg
• PKA: 10.52±0.70(Predicted)
• Flash Point: 62.2 °C
• PSA: 29.26000
• Density: 0.92 g/cm³
• LogP: 1.51820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.5% ^*data from raw suppliers

(1S,2S)-N1,N1-Dimethylcyclohexane-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine

There total 5 articles about (1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1S,2S)-N,N-dimethyl-N’-Phthaloyl-1,2-diaminocyclohexane → (1S,2S)-N,N-dimethylcyclohexane-1,2-diamine (894493-95-9)

Guidance literature:

With hydrazine; In ethanol; water;

DOI:10.1039/c5ob00492f

Reference yield: 86.0%

5-((E)-1-(((1S,2S)-2-dimethylaminocyclohexyl)imino)ethyl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione → (1S,2S)-N,N-dimethylcyclohexane-1,2-diamine (894493-95-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 60 ℃; for 36h;

DOI:10.1021/ol500637x

Reference yield: 65.0%

7-azabicyclo[3.1.0]heptane + trans-2-chloro-dimethyl-aminocyclohexane + N,N-dimethyl-N'-benzyl-1,2-cyclohexanediamine (620597-07-1) + methanesulfonyl chloride (124-63-0) + benzylamine (100-46-9) → (1S,2S)-N,N-dimethylcyclohexane-1,2-diamine (894493-95-9)

Guidance literature:

With sodium hydroxide; HClO₄; NaH; dimethyl amine; Pd-C; In tetrahydrofuran; mineral oil;

upstream raw materials:

N,N-dimethyl-N'-benzyl-1,2-cyclohexanediamine

methanesulfonyl chloride

benzylamine

7-azabicyclo[4.1.0]heptane

Downstream raw materials:

N-((1S,2S)-2-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)cyclohexyl)-1,1,1-trifluoromethanesulfonamide

Refernces

• 1、 Massolo, Elisabetta,Benaglia, Maurizio,Genoni, Andrea,Annunziata, Rita,Celentano, Giuseppe,Gaggero, Nicoletta. "Stereoselective reaction of 2-carboxythioesters-1,3-dithiane with nitroalkenes: An organocatalytic strategy for the asymmetric addition of a glyoxylate anion equivalent". supporting information. p. 5591 - 5596. Retrieved 2015/05/27.
• 2、 Li, Bang-Jing,Jiang, Lin,Liu, Min,Chen, Ying-Chun,Ding, Li-Sheng,Wu, Yong. "Asymmetric Michael addition of arylthiols to α,β-unsaturated carbonyl compounds catalyzed by bifunctional organocatalysts". . p. 603 - 606. Retrieved 2007/10/03.