[2,7]Naphthyridin-1-ylamine

Base Information

• Chemical Name: [2,7]Naphthyridin-1-ylamine
• CAS No.: 27225-00-9
• Molecular Formula: C8H7N3
• Molecular Weight: 145.164
• Hs Code.: 2933990090
• Mol file: 27225-00-9.mol

Synonyms:2,7-Naphthyridin-1-amine;

Chemical Property of [2,7]Naphthyridin-1-ylamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.724
• Boiling Point: 363.672 °C at 760 mmHg
• PKA: 5.54±0.30(Predicted)
• Flash Point: 201.242 °C
• PSA: 52.53000
• Density: 1.293 g/cm³
• LogP: 1.14210
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2,7-naphthyridin-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,7]Naphthyridin-1-ylamine

There total 5 articles about [2,7]Naphthyridin-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

1-amino-1,2-dihydro-2,7-naphtyridimide (80935-80-4) → 2,7-naphthyridin-1-ylamine (27225-00-9)

Guidance literature:

With potassium permanganate; at -40 ℃; Product distribution;

Reference yield: 4.0%

1-chloro-[2,7]naphthyridine (69042-30-4) → [2,7]naphthyridine (253-45-2) + 2,7-naphthyridin-1-ylamine (27225-00-9)

Guidance literature:

With ammonia; potassium amide; Mechanism; also bromo-substituted naphthyridine, deutero-substituted derivatives, other products;

Reference yield:

3-cyano-4-methylpyridine (5444-01-9) → 2,7-naphthyridin-1-ylamine (27225-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 72 h / 110 - 120 °C

2: ammonium formate; acetic acid / 20 h / 115 °C

With ammonium formate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

1-chloro-[2,7]naphthyridine

1-amino-1,2-dihydro-2,7-naphtyridimide

3-cyano-4-methylpyridine

N,N-dimethyl-2-(3-cyano-pyridin-4-yl)etheneamine

Downstream raw materials:

4-bromo-2,7-naphthyridin-1-ylamine

Refernces

• 1、 Haak, H. J. W. van den,Plas, H. C. van der. "The amination of halogeno-2,7- and 1,8-naphthyridines". . p. 235 - 238. Retrieved 2007/10/02.