7-FLUOROISOQUINOLINE

Base Information

• Chemical Name: 7-FLUOROISOQUINOLINE
• CAS No.: 1075-12-3
• Molecular Formula: C9H6FN
• Molecular Weight: 147.15
• Hs Code.: 2933499090
• Mol file: 1075-12-3.mol

Synonyms:7-FLUOROISOQUINOLINE

Chemical Property of 7-FLUOROISOQUINOLINE

Chemical Property:

• PSA: 12.89000
• LogP: 2.37390
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Fluoroisoquinoline 98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-FLUOROISOQUINOLINE

There total 12 articles about 7-FLUOROISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H7FO2 → 7-fluoroisoquinoline (1075-12-3)

Guidance literature:

With ammonium hydroxide; In methanol; dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-0037-1610223

Reference yield:

N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine (73261-94-6) → 7-fluoroisoquinoline (1075-12-3)

Guidance literature:

N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine; With chloroformic acid ethyl ester; In tetrahydrofuran; at -10 ℃;

With phosphorous acid trimethyl ester; In tetrahydrofuran;

With titanium tetrachloride; In tetrahydrofuran; dichloromethane; Reflux;

Reference yield:

1-chloro-7-fluoroisoquinoline (630422-89-8) → 7-fluoroisoquinoline (1075-12-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; sodium hydroxide; In methanol;

upstream raw materials:

3-Fluorobenzaldehyde

N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine

5-fluoro-2-methylbenzoic acid

5-fluoro-2-methylbenzamide

Downstream raw materials:

7-fluoroisoquinoline-1(2H)-one

1-chloro-7-fluoroisoquinoline

Refernces

• 1、 Pearson, Stuart E.,Fillery, Shaun M.,Goldberg, Kristin,Demeritt, Julie E.,Eden, Jonathan,Finlayson, Jonathan,Patel, Anil. "Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions". . p. 4963 - 4981. Retrieved 2018/12/13.