630422-89-8

Usage

Uses

Used in Pharmaceutical Industry:
1-chloro-7-fluoroisoquinoline is used as a key intermediate in the synthesis of various pharmaceuticals for its antimicrobial, anticancer, and anti-inflammatory properties. Its unique structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical sector, 1-chloro-7-fluoroisoquinoline is utilized as a building block for the creation of novel pesticides and insecticides. Its biological activity contributes to the development of more effective and environmentally friendly agrochemicals.
Used in Dyes and Pigments Industry:
1-chloro-7-fluoroisoquinoline is employed as a precursor in the production of various types of dyes and pigments. Its chemical properties enable the creation of colorants with enhanced stability, brightness, and application versatility.
Used in Materials Science:
Due to its structural and functional properties, 1-chloro-7-fluoroisoquinoline has potential applications in materials science, such as the development of advanced materials with unique optical, electronic, or mechanical properties. Its versatility allows for its use in various high-tech applications, including sensors, optoelectronics, and nanotechnology.

Upstream product

• 175278-28-1 5-fluoro-2-methylbenzamide 
• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 410086-27-0 7-fluoroisoquinoline-1(2H)-one 
• 1075-12-3 7-fluoroisoquinoline 
• 73261-94-6 N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 1075-12-3 7-fluoroisoquinoline 

Relevant academic research and scientific papers

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

Method for synthesizing 4-bromo-7-fluoroisoquinoline

The invention provides a method for synthesizing 4-bromo-7-fluoroisoquinoline. The method is characterized in that 5-fluoro-2-methyl-benzoic acid is taken as a starting material and is subjected to areaction to generate 7-fluoroisoquinoline, and lastly the 7-fluoroisoquinoline is subjected to a bromination reaction to obtain the 4-bromo-7-fluoroisoquinoline. The method for synthesizing the 4-bromo-7-fluoroisoquinoline provided by the invention has the advantages of simple synthesizing route, reasonable process selection, low raw material cost, adoption of readily-available raw material, convenience in operation and posttreatment, high yield, no use of highly-toxic reagents, easiness in performing scale-up experiments, realization of large-scale production and the like.

ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES

The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.