(R)-1-Pyridin-2-yl-ethylamine

Base Information

• Chemical Name: (R)-1-Pyridin-2-yl-ethylamine
• CAS No.: 45695-03-2
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 889-374-1
• Nikkaji Number: J64.089A
• Mol file: 45695-03-2.mol

Synonyms:(R)-1-Pyridin-2-yl-ethylamine;45695-03-2;(R)-1-(Pyridin-2-yl)ethanamine;(R)-1-(2-Pyridyl)ethylamine;(1R)-1-pyridin-2-ylethanamine;(1R)-1-(pyridin-2-yl)ethan-1-amine;(R)-1-Pyridin-2-ylethylamine;MFCD07776289;SCHEMBL176779;PDNHLCRMUIGNBV-ZCFIWIBFSA-N;(1R)-1-(2-pyridinyl)ethanamine;(r)-1-(pyridin-2-yl)ethylamine;BCP21569;CS-M2154;[(1R)-1-(2-pyridinyl)ethyl]amine;AKOS010367117;BS-13103;EN300-53091

Chemical Property of (R)-1-Pyridin-2-yl-ethylamine

Chemical Property:

• Boiling Point: 194.5±15.0 °C(Predicted)
• PKA: 9.05±0.39(Predicted)
• PSA: 38.91000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

(+)-2-[(1R)-1-Aminoethyl)]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=N1)N
• Isomeric SMILES: C[C@H](C1=CC=CC=N1)N

Technology Process of (R)-1-Pyridin-2-yl-ethylamine

There total 2 articles about (R)-1-Pyridin-2-yl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpyridine (1122-62-9) + 1,4-diaminobutane (110-60-1) → 1-pyrroline (5724-81-2) + (S)-1-(2-pyridyl)ethylamine (27854-90-6) + (R)-1-(pyridin-2-yl)ethanamine (27854-90-6,42088-91-5,42732-17-2,45695-03-2)

Guidance literature:

With spuC gene from Pseudomonas chlororaphis subsp. aureofaciens; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc02102f

Reference yield:

2-acetylpyridine (1122-62-9) + bishydrochloride salt of cis-1,4-diamino-but-2-ene (87227-77-8,99240-70-7,114118-70-6,119874-79-2) → pyrrole (109-97-7,30604-81-0) + (R)-1-(pyridin-2-yl)ethanamine (27854-90-6,42088-91-5,42732-17-2,45695-03-2)

Guidance literature:

With transaminase ATA-025; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 48h; pH=7.5; Enzymatic reaction;

DOI:10.1002/adsc.201501066

Reference yield: 99.0%

(R)-1-(pyridin-2-yl)ethanamine (27854-90-6,42088-91-5,42732-17-2,45695-03-2) + (2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid (81396-84-1) → benzyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(((R)-1-(pyridin-2-yl)ethyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃; for 20h; Inert atmosphere;

DOI:10.1002/adsc.202100301

upstream raw materials:

2-acetylpyridine

bishydrochloride salt of cis-1,4-diamino-but-2-ene

1,4-diaminobutane

Downstream raw materials:

[R]-7-[2-(5-trifluoromethyl-pyridin-2-yl)-benzoylamino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-ethyl)-amide

[R]-7-{[2-(4-trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-quinoline-3-carboxylic acid (1-pyridin-2-yl-ethyl)-amide

7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-(2-pyridinyl)ethyl]amino}-3-quinolinecarboxamide

I-BET151

Refernces

• 1、 Martínez-Montero, Lía,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván. "But-2-ene-1,4-diamine and But-2-ene-1,4-diol as Donors for Thermodynamically Favored Transaminase- and Alcohol Dehydrogenase-Catalyzed Processes". supporting information. p. 1618 - 1624. Retrieved 2016/10/13.