acetaldehyde compound with thieno[2,3-b]pyridine (1:1)

Base Information

• Chemical Name: acetaldehyde compound with thieno[2,3-b]pyridine (1:1)
• CAS No.: 89723-19-3
• Molecular Formula: C₉H₇NOS
• Molecular Weight: 177.227
• Mol file: 89723-19-3.mol

Synonyms:ETHANONE, 1-THIENO[2,3-B]PYRIDIN-6-YL-;Thieno[2,3-b]pyridine, ethanone deriv.;

Chemical Property of acetaldehyde compound with thieno[2,3-b]pyridine (1:1)

Chemical Property:

• PSA: 58.20000
• LogP: 2.49890

Purity/Quality:

1-thieno[2,3-b]pyridin-6-yl-Ethanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of acetaldehyde compound with thieno[2,3-b]pyridine (1:1)

There total 5 articles about acetaldehyde compound with thieno[2,3-b]pyridine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2-dimethyl-5-<1-amino-1-(6-thieno<2,3-b>-pyridyl)>methylene-1,3-dioxane-4,6-dione (89723-18-2) → 6-acetylthieno<2,3-b>pyridine (89723-19-3)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

Reference yield: 39.0%

ethanol (64-17-5) + 2,2-dimethyl-5-<1-amino-1-(6-thieno<2,3-b>-pyridyl)>methylene-1,3-dioxane-4,6-dione (89723-18-2) → 6-acetylthieno<2,3-b>pyridine (89723-19-3) + ethyl 3-oxo-3-(6-thieno<2,3-b>pyridyl)propanoate (89723-21-7)

Guidance literature:

With boron trifluoride diethyl etherate; for 48h; Heating;

Reference yield:

methyl thieno<2,3-b>pyridine-6-imidate (89723-15-9) → 6-acetylthieno<2,3-b>pyridine (89723-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / triethylamine / CHCl₃ / 12 h / Heating

2: boron trifluoride etherate / 48 h / Heating

With boron trifluoride diethyl etherate; triethylamine; In chloroform;

upstream raw materials:

ethanol

2,2-dimethyl-5-<1-amino-1-(6-thieno<2,3-b>-pyridyl)>methylene-1,3-dioxane-4,6-dione

6-cyanothieno<2,3-b>pyridine

methyl iodide

Refernces