(E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate
CAS No.:282734-70-7
Molecular Formula:C17H14N2O4S
Molecular Weight:342.3691
Hs Code.:
Mol file:282734-70-7.mol

Synonyms:methyl (E)-3-[(1-phenylsulfonyl)-1H-pyrrolo [2,3-b]-pyridin-2-yl]propenoate;methyl (E)-3-(furan-2-yl)-2-[(2-hydroxy-6-oxocyclohex-1-enyl)methyl]acrylate;(E)-methyl 3-(furan-2-yl)-2-((2-hydroxy-6-oxocyclohex-1-enyl)methyl)acrylate;

Suppliers and Price of (E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of (E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:563.352°C at 760 mmHg
Flash Point:294.505°C
PSA：86.64000
Density:1.32g/cm³
LogP:3.54030

Purity/Quality:: 99.3% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate

There total 2 articles about (E)-methyl 3-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 282734-63-8
2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 282734-70-7
methyl (E)-3-[(1-phenylsulfonyl)-1H-pyrrolo [2,3-b]-pyridin-2-yl]propenoate

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 3h;
DOI:10.1016/S0040-4020(00)00231-3

Reference yield:

: 143141-23-5
1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine

: 282734-70-7
methyl (E)-3-[(1-phenylsulfonyl)-1H-pyrrolo [2,3-b]-pyridin-2-yl]propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / TMEDA; LDA; iodine / tetrahydrofuran; heptane / 0.5 h / -22 °C

2: 56 percent / Pd(OAc)2; PPh₃; Et₃N / dimethylformamide / 3 h / 90 °C

With palladium diacetate; N,N,N,N,-tetramethylethylenediamine; iodine; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; N,N-dimethyl-formamide; 1: Iodination / 2: Addition;
DOI:10.1016/S0040-4020(00)00231-3