tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate
CAS No.:733757-79-4
Molecular Formula:C₁₂H₁₆F₃NO₄
Molecular Weight:295.259
Hs Code.:2933399090
European Community (EC) Number:936-955-3
DSSTox Substance ID:DTXSID70693140
Mol file:733757-79-4.mol

Synonyms:733757-79-4;tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate;tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate;SCHEMBL1007010;DTXSID70693140;MFCD18910073;AKOS015991490;KF-0702;FT-0710493;1-tert-butoxycarbonyl-3-(trifluoroacetyl)-4-piperidinone;tert-butyl4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Suppliers and Price of tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate >95%
1g
$ 245.00

Matrix Scientific
tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate >95%
500mg
$ 194.00

Matrix Scientific
tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate >95%
5g
$ 735.00

Chemenu
tert-butyl4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate 95+%
1g
$ 312.00

Atlantic Research Chemicals
tert-Butyl4-Oxo-3-(trifluoroacetyl)piperidine-1-carboxylate 95%
1gm:
$ 180.26

AK Scientific
tert-Butyl4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate
500mg
$ 311.00

Total 9 raw suppliers

Chemical Property of tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate

Chemical Property:

PSA：63.68000
LogP:1.88180
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:295.10314248
Heavy Atom Count:20
Complexity:425

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(=O)C(C1)C(=O)C(F)(F)F

Technology Process of tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate

There total 2 articles about tert-Butyl 4-oxo-3-(trifluoroacetyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 407-25-0
trifluoroacetic anhydride

: 217807-98-2
4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester

: 733757-79-4
tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃;
DOI:10.1016/j.bmcl.2010.08.063

Reference yield: 75.0%

: 383-63-1
ethyl trifluoroacetate,

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 733757-79-4
tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.416667h; Inert atmosphere;

ethyl trifluoroacetate,; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 733757-79-4
tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

: 60-34-4
methylhydrazine

: 794451-94-8
1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 853784-42-6
2-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine

Guidance literature:: tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate; methylhydrazine; Heating;

With hydrogenchloride; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2005.03.012