ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Base Information

Chemical Name:ethyl 3-amino-2,2-difluoro-3-phenylpropanoate
CAS No.:381245-54-1
Molecular Formula:C11H13F2NO2
Molecular Weight:229.227
Hs Code.:
Mol file:381245-54-1.mol

Synonyms:Benzenepropanoic acid, b-amino-a,a-difluoro-, ethyl ester;Ethyl 3-amino-2,2-difluoro-3-phenylpropanoate;

Suppliers and Price of ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 3-AMINO-2,2-DIFLUORO-3-PHENYLPROPANOATE 95.00%
5MG
$ 501.56

Total 7 raw suppliers

Chemical Property of ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Chemical Property:

PSA：52.32000
LogP:2.58510

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 3-AMINO-2,2-DIFLUORO-3-PHENYLPROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

There total 4 articles about ethyl 3-amino-2,2-difluoro-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171251-47-1
ethyl 3-azido-2,2-difluoro-3-phenylpropanoate

: 381245-54-1
ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 1h; Ambient temperature;
DOI:10.1248/cpb.45.1793

Reference yield:

: 92207-60-8
ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate

: 381245-54-1
ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 5.1 h

2: 39 percent / n-Bu₄NBr, NaN₃ / dimethylformamide / 40 h / 65 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 1 h / Ambient temperature

With sodium azide; tetrabutylammomium bromide; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1793

Reference yield:

: 100-52-7
benzaldehyde

: 381245-54-1
ethyl 3-amino-2,2-difluoro-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / zinc / tetrahydrofuran / 0.25 h / Heating

2: 97 percent / Et₃N / CH₂Cl₂ / 5.1 h

3: 39 percent / n-Bu₄NBr, NaN₃ / dimethylformamide / 40 h / 65 °C

4: H₂ / 10percent Pd/C / ethyl acetate / 1 h / Ambient temperature

With sodium azide; tetrabutylammomium bromide; hydrogen; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1793